月见草油对高脂大鼠血脂及SOD、CAT活性的影响

目的：观察月见草油对高脂大鼠血脂及血清SOD、全血CAT活性的影响。方法：40只SD健康雄性大鼠随机分成四组：（1）正常对照组：喂饲基础饲料＋2．5ml/kg.d NS灌胃。（2）高脂对照组：喂饲高脂饲料＋2．5ml/kg.d NS灌胃。（3）月见草油低剂量组：喂饲高脂饲料＋月见草油2．5ml/kg.d灌胃。（4）月见草油高剂量组：喂饲高脂饲料＋月见草油5．0ml/kg.d灌胃。实验期30d。结果：月见草油使高脂大鼠血清HDL－C明显升高（P＜0．01），TC、LDL－C明显降低（P＜0．01），TG有降低趋势但无显著性差异，CAT活性显著升高（P＜0．01），SOD活性显著升高（P＜0．05）。结论：月见草油可以降低血脂，提高SOD、CAT活性。

Effect of Eveningross Oil on Serum Lipids and Activities of SOD and CAT in Hyperlipidemic Rats

Objective: The effect of Eveningros oil on serum lipids and activities of SOD and CAT were investigated in rats on high fat diet during an experimental period of 4 weeks. Methods: Forty healthy male SD rats were randomly divided into 4 groups: normal control group living on common diet and being given 2.5ml/kg/d normal saline by gastrogavage; high fat diet control group living on high fat diet and being given 2.5ml/kg/d normal saline by gastrogavage; high fat diet group A living on high fat diet and being given 2.5ml/kg/d eveningross oil; and high fat diet group B living on high fat diet and being given 5.0ml/kg/d eveningross oil. Results: Compared with control groups, HDL-C level and activities of SOD and CAT of experimental group were significantly increased (P<0 01), while TC, LDL-C decreased (P<0.01). TG decreased but no significance was found. Conclusions: Oral administration of eveningross oil can significantly decrease the level of TC and LDL-C and increase the level of HDL-C and the activities of SOD and CAT in rats.