A novel analgesic pyrazine derivative from the leaves of Croton tiglium L |
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| Authors: | Wu Xin-An Zhao Yi-Min Yu Neng-Jiang |
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| Affiliation: | Laboratory of Phytochemistry, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. |
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| Abstract: | ![]()
A novel analgesic pyrazine derivative, named crotonine, was isolated from the leaves of Croton tiglium L. The structure was elucidated as 2-(furan-2-yl)-5-(2,3,4-trihydroxy-butyl)-1,4-diazine by spectroscopic analysis. Crotonine inhibited remarkably the acetic acid-induced writhing in mice. |
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