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N-nitroso compounds, nitrite and pH in human fasting gastric juice |
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| Authors: | Vu, B.Dang Paul, J.L. Gaudric, M. Guerre, J. Younger, J. Ekindjian, O.G. |
| Affiliation: | Biochemistry 1Biochemistry and Gastro-enterology, Hospital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France |
| Abstract: | Total N-nitroso compounds, ethyl acetate-extractable N-nitrosocompounds and nitrite were measured in 146 samples of fastinggastric juice to investigate their relationship with pH. A positivecorrelation was found between pH and extractable N-nitroso compounds(r = 0.206, P < 0.02), whereas total N-nitroso compoundswere pH-independent It was inferred that pre-cancerous conditionsassociated with high gastric pH may be produced by an increasein the extractable N-nitroso compounds, which constitue onlya small fraction of the total gastric N-nitroso compounds. |
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