| 旋覆代赭汤含药血清对大鼠胃平滑肌细胞收缩效应的影响 |
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| 引用本文： | 陶春晖,邱明义,石拓,胡继鹰,李静,刘念. 旋覆代赭汤含药血清对大鼠胃平滑肌细胞收缩效应的影响[J]. 湖北中医药大学学报, 2010, 12(4): 10-12 |
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| 作者姓名： | 陶春晖 邱明义 石拓 胡继鹰 李静 刘念 |
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| 作者单位： | 湖北中医药大学,湖北,武汉,430061;武汉市中西医结合医院,湖北,武汉,430022;广州军区武汉总医院,湖北,武汉,430070;武汉市中医医院,湖北,武汉,430014 |
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| 基金项目： | 湖北省教育厅科研课题 |
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| 摘 要： | 目的观察旋覆代赭汤含药血清引起大鼠胃不同部位单个游离胃平滑肌细胞收缩的不同效应。方法按照血清药理学通法制备大鼠旋覆代赭汤含药血清,并利用Ⅱ型胶原酶消化得到大鼠胃平滑肌细胞悬液,将含药血清加入到细胞悬液中,用显微测微尺随机测量25-50个细胞长轴的长度。对比给药前后胃平滑肌细胞收缩活动变化,细胞收缩活动变化以相对于对照细胞长度增加或缩小的百分数表示,负数表示收缩,正数表示松弛。结果旋覆代赭汤含药血清对大鼠胃平滑肌细胞收缩有促进作用,随剂量的增加细胞收缩活动逐渐增强(P0.05)。其中,旋覆代赭汤含药血清对大鼠胃窦平滑肌细胞的收缩作用最强。结论旋覆代赭汤具有较明显的促胃动力作用。
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| 关 键 词： | 旋覆代赭汤 含药血清 胃平滑肌细胞 收缩 |
Effects of Xuanfu Daizhe Decoction medicated serum on contraction of Gastric Smooth Muscle Cells in Rats |
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| TAO Chunhui,QIU Mingyi,SHI Tuo,HU Jiying,LI Jing,LIU Nian. Effects of Xuanfu Daizhe Decoction medicated serum on contraction of Gastric Smooth Muscle Cells in Rats[J]. Journal of Hubei University of Chinese Medicine, 2010, 12(4): 10-12 |
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| Authors: | TAO Chunhui QIU Mingyi SHI Tuo HU Jiying LI Jing LIU Nian |
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| Affiliation: | TAO Chunhui1,QIU Mingyi2,SHI Tuo2,HU Jiying1,LI Jing3,LIU Nian4 (1.Hubei University of Chinese Medicine,Wuhan 430061,Hubei,2.Wuhan Chinese and Western Medicine Hospital,Wuhan 430022,3.Wuhan General Hospital of Guangzhou Military Command,Wuhan 430070,4.Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430014,Hubei) |
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| Abstract: | Objective To observe the different effect of Xuanfu Daizhe Decoction medicated serum induced contraction of single dissociated gastric smooth muscle cells in different parts of the rat's stomach.Methods The common method of serum pharmacology was applied to prepare the serum from rats medicated with Xuanfu Daizhe Decoction.Then the type II collagenase was used to digest the rat's stomach issue to get the cell suspension of rat's gastric smooth muscle cells.The medicated serum was added into the cell suspens... |
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| Keywords: | Xuanfu Daizhe Decoction Medicated serum Gastric smooth muscle cells contraction |
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