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| 强啡肽A(1-17)在脊髓的致瘫作用及其与神经毒作用的相关性 | |
| 引用本文： | 崔彩莲,吴鎏桢,韩济生. 强啡肽A(1-17)在脊髓的致瘫作用及其与神经毒作用的相关性[J]. 药学学报, 1997, 32(2): 85-89 |
| 作者姓名： | 崔彩莲 吴鎏桢 韩济生 |
| 作者单位： | 北京医科大学神经科学研究中心 |
| 摘 要： | 在以行为学为观察指标(甩尾镇痛和斜板实验)的基础上,用组织学方法探讨大剂量强啡肽A在脊髓水平的致瘫作用与其神经毒作用的关系。结果表明,给大鼠蛛网膜下腔(it)注射强啡肽A(1-17)20nmol·L-1,共10μl,给药后5～10min即引起大鼠后肢不可逆性瘫痪、甩尾反射被抑制长达40h以上。大鼠脊髓组织学检查发现,腰、骶段脊髓前角运动神经元大量坏死或严重变性、以腰段损伤最为显著(运动神经元减少87.2%),其次是骶段(减少69.6%),胸段损伤不明显(减少8.2%)。 |
| 关 键 词： | 强啡肽A(1-17) 脊髓前角 运动神经元 瘫痪 神经毒性 |
| 收稿时间： | 1996-04-18 |
CORRELATION BETWEEN MOTOR PARALYSIS AND NEUROTOXICITY INDUCED BY INTRATHECAL DYNORPHIN A(1-17) IN RATS |
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| CL Cui,LZ Wu and JS Han. CORRELATION BETWEEN MOTOR PARALYSIS AND NEUROTOXICITY INDUCED BY INTRATHECAL DYNORPHIN A(1-17) IN RATS[J]. Acta pharmaceutica Sinica, 1997, 32(2): 85-89 | |
| Authors: | CL Cui LZ Wu JS Han |
| Affiliation: | Neuroscience Research Center, Beijing Medical University, Beijing 100083. |
| Abstract: | Intrathecal(i.t.) injection of 10 microliters of dynorphin A(1-17) 20 nmol.L-1 per rat resulted in irreversible hind limb paralysis and suppression of the tail-flick reflex lasting for up to 40 h. The dual effects of dynorphin appeared 5-10 min after the i.t. administration. Histologic examination of the spinal cord in the rats demonstrated dead and/or dying and degenerated motor-neurons in the ventral horn located predominately in the lumbar segment(a 87.2% reduction of the number of motor neurons, P < 0.01) and also in a lesser degree in sacral segment(-69.6%, P < 0.05). The thoracic segment was essentially normal(-8.2%, P > 0.05). |
| Keywords: | Dynorphin A(1 17) Motor neurons in spinal cord Ventral horn Paralysis Neurotoxicity |
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