Genetic susceptibility to gluten sensitive enteropathy in Irish setter dogs is not linked to the major histocompatibility complex |
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| Authors: | A Polvi OA Garden RS Houlston M Maki RM Batt J Partanen |
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| Institution: | Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service, Helsinki, Finland;Department of Small Animal Medicine and Surgery, Royai Veterinary College, University of London, Hertfordshire, United Kingdom;Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom;Institute of Medical Technology, University of Tampere, Tampere, Finland;Department of Pediatrics, Tampere University Hospital, Tampere, Finland |
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| Abstract: | Abstract: Gluten sensitive enteropathy (GSE) in Irish setter dogs has been proposed as an animal model for human celiac disease (CD), in which the major histocompatibility complex (MHC) class II alleles HLA DQAl*0501 and DQBl*0201 play an important role. To investigate whether an orthologous MHC class II region is involved in canine GSE, we undertook a linkage study in two large families of gluten sensitive Irish setter dogs. A total of 44 dogs in these pedigrees were genotyped for DQA1, DQB1 and C.2202 alleles, along with 30 unrelated healthy Irish setters. No genetic linkage between the DQ or C.2002 loci and GSE was detected. In contrast to CD, susceptibility to canine GSE does not appear to be determined by variation within the MHC class II gene cluster. Therefore, canine GSE may not be an appropriate model for CD, but nevertheless remains an important disease for advancing knowledge of pathological processes in the intestine. |
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| Keywords: | animal model canine celiac disease DLA gluten sensitive enteropathy HLA linkage analysis nucleotide sequence |
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