解郁活血方对脑梗死后抑郁症患者神经功能康复的影响

目的:研究解郁活血方对脑梗死后抑郁症患者抑郁症状和神经功能康复的影响.方法:将54例脑梗死后抑郁症患者随机分为抑郁症对照组(18例)、氟西汀治疗组(18例)和解郁活血方治疗组(18例);另设脑梗死后无抑郁症对照组18例.观察治疗前、治疗后30 d和60 d的Zung抑郁自评量表(SDS)、改良爱丁堡与斯堪的那维亚量表(MESSS)和日常生活能力(ADL)评分.结果:解郁活血方治疗组治疗后30 d、60 d SDS评分与治疗前和同期的抑郁症对照组比较有显著性差异(P<0.05或P<0.01),治疗后30 d和60 d MESSS评分和ADL评分与治疗前和同期的抑郁症对照组比较也有显著性差异(P<0.05或P<0.01);解郁活血方治疗组与氟西汀治疗组间疗效无明显差异,但解郁活血方治疗组的副作用少且症状轻.结论:解郁活血方可明显改善脑梗死后抑郁症患者的抑郁症状,同时还能促进其神经功能康复.

Influence of Jieyu Huoxue Decoction on rehabilitation of patients with depression after cerebral infarction

Objective:To study the influence of Jieyu Huoxue Decoction on rehabilitation of patients with depression after cerebral infarction.Methods:Fifty four patients suffered from the depression after acute cerebral infarction were randomly divided into three groups:depression control group, fluoxetine treated group and Jieyu Huoxue Decoction treated group.Eighteen patients of cerebral infarction without depression were enrolled in the no depression control group randomly. The Zung self-rating depression scale (SDS), the modified Edinburgh-Scandinavia stroke scale (MESSS) and the activities of daily living (ADL) were evaluated before treatment, 30 and 60 days after treatment. Results:After 30 and 60 days of treatment, SDS evaluation of the Jieyu Huoxue Decoction treated group showed significant difference as compared with the condition before treatment and that of the depression control group (P<0.05 or P<0.01), MESSS evaluation and ADL evaluation also showed significant difference as compared with the condition before treatment and that of the depression control group (P<0.05 or P<0.01);there was no obvious difference between the fluoxetine treated group and the Jieyu Huoxue Decoction treated group, but the Jieyu Huoxue Decoction treated group showed fewer symptoms and less side effect. Conclusion:Jieyu Huoxue Decoction can not only relieve depression after cerebral infarction, but also improve neurological functions.