| 盐酸氯卡色林消旋体的合成工艺改进 |
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| 引用本文： | 王昊苏,朱亦龙,吴 飞,王德才. 盐酸氯卡色林消旋体的合成工艺改进[J]. 药学与临床研究, 2014, 22(3): 237-238 |
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| 作者姓名： | 王昊苏 朱亦龙 吴 飞 王德才 |
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| 作者单位： | 南京工业大学药学院,南京210009 |
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| 摘 要： | 改进盐酸氯卡色林消旋体的合成工艺,以对氯苯乙腈为起始原料,经还原得到中间体对氯苯乙胺,与2-氯丙酰氯反应,再经傅克烷基化反应成环,然后使用硼氢化钠、三氯化铝还原体系还原酰胺,最后成盐,得到目标产物,总收率达25.0%。
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| 关 键 词： | 盐酸氯卡色林消旋体 合成 减肥药 |
| 收稿时间： | 2014-01-16 |
| 修稿时间： | 2014-03-06 |
Improvement the Synthesis Process of Lorcaserin Hydrochloride Racemate |
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| WANG Hao-su,ZHU Yi-long,WU Fei and WANG De-cai. Improvement the Synthesis Process of Lorcaserin Hydrochloride Racemate[J]. Pharmacertical and Clinical Research, 2014, 22(3): 237-238 |
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| Authors: | WANG Hao-su ZHU Yi-long WU Fei WANG De-cai |
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| Affiliation: | ( School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing 210009, China) |
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| Abstract: | This study is to synthesize lorcaserin hydrochloride racemate and improve the process. The 4-chlorophenethylamine was synthesized from 4-chlorobenzyl cyanide by reduction, and then it was reacted with 2-chloropropionyl chloride, through cyclization, reduction by sodium borohydride and aluminum chloride,finally through salt formation, to form lorcaserin hydrochloride racemate, with an overall yield of 25.0%. |
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| Keywords: | Lorcaserin hydrochloride racemate Synthesis Antiobesity agent |
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