光动力疗法治疗酒渣鼻的疗效

目的观察光动力疗法（photodynamictherapy，PI）T）治疗不同类型酒渣鼻的疗效及其安全性。并与外用10％磺胺醋酰钠、5％硫磺复合霜剂的疗效对比，确定两种治疗方法的优劣。方法酒渣鼻患者43例，随机分为2组，其中23例为PDT组，20例为外用药组。PDT组每7～10d行PDT治疗1次，共治疗3次；外用药组每日用药治疗2次。连续30d。治疗前后拍照片存档，医师根据照片单盲评价症状改薄程度，皮损减轻60％以上视为治疗有效；患者自我记录不良反应，并评价其严承程度；治疗前后要求患者填写皮肤病生活质量指标量表，评价生活质量改善程度。结果PDT组治疗1个月后，总有效牢为65％，其中丘疹脓疱型患者有效率为71％，红斑毛细血管扩张型患者有效，卒为50％；外用药组治疗总有效率为35％。PDT组和外用药组治疗总有效率差异有统计学意义（P％0．05）。PI）T组患者生活质量改善程度优于外用药组；PDT治疗和外用药治疗均没有不可逆性不良反应产生。结论PDT治疗酒渣鼻安全有效，可明显改善患者生活质量，出现的不良反应少且可逆。

Efficacy of photodynamic therapy on rosacea

Objective To investigate the efficacy and safety of photodynamic therapy （PI）T） in the treatment of different types of rosacea, and to evaluate its benefit by comparing its efficacy with 10% sodium sul/acetamide and 5% sulfur emollient foam. Methods Forty-three subjects with rosacea were enrolled in this study. They were randomized to he treated with PDT （twenty-three subjects） or 10% sodium sulfacetamide and 5% sulfur emollient foam （twenty subjects）. PDT group subjects re ceived PDT once every seven to ten days for three times while the 10~ sodium sulfacetamide or 50% sulfur emollient foam was applied 2 times per day for thirty days in the other group. Digital photo graphs were taken before and after one month of treatment in both groups. Blinded independent physi cians graded improvement based on these photographs utilizing a percentile evaluation scale. A more than sixty percent remission proved the treatment to he effective. All the complications occurred dur ing the therapy were taken notes and their severity was classified by the subjects. Two dermatology life quality index forms were completed before and after treatment by the subjects to evaluate the change in terms of their quality of life. Results After one month of treatment. PDT proved to be ef- fective on sixty-five percent of subjects （seventy-one percent on papulopustular rosacea and fifty per cent on erythematotelangieetatie rosacea）. The emollient foam proved to be effective on thirty five per- cent of subjects. Statistically significant difference was observed between the overall effective rate of PDT and emollient foam （P~0.05）. In addition, a greater improvement in terms of the quality of life was experienced by the PDT group subjects. No irreversible adverse event was ohserved in both groups during the study. Conclusions PDT proves to be an effective and safe treatment for rosacea with satisfactory efficacy, significant improvement in patients＇ quality of life and few irreversible side effects.