注射用血栓通对2型糖尿病GK大鼠视网膜病理结构的影响

目的]注射用血栓通(冻干)(XST)由三七主根为原料制成,本文探讨了其对GK大鼠糖尿病视网膜病理结构的影响,为治疗糖尿病视网膜并发症提供实验依据。方法]GK 2型糖尿病大鼠随机分为模型组,100 mg/kg血栓通组,50 mg/kg血栓通组。血栓通组每天给予血栓通腹腔注射,另设Wistar对照组,对照组和模型病组给予等量的生理盐水,大鼠均于屏障环境中饲养治疗60 d。结果]血栓通对糖尿病大鼠的体质量、血糖未见影响,能有效抑制糖尿病大鼠视网膜的收缩,改善各层的细胞结构。结论]血栓通可改善GK2型糖尿病大鼠视网膜病理结构。

Effect of injection of Xueshuantong on retinal pathological structure of GK type 2 diabetic rats

Objective] Injection with Xueshuantong (freeze-dried) (XST) from the main root of Panax notoginseng made of raw materials, this paper was studied the effect of the pathological changes of diabetic retinopathy in Goto-Kakizaki (GK) rats, for the treatment of diabetic retinal complications to provide experimental basis.Methods] GK type 2 diabetic rats were randomly divided into model group, 100 mg/kg XST group, 50 mg/kg XST group, intraperitoneal injection of XST per day, barrier treatment for 60 days. There was another Wistar control group. The control group and the model group were given the same amount of saline.Results] The body weight and blood glucose of diabetic rats were not affected by thrombus, which could effectively inhibit the contraction of diabetic retina and improve the cell structure of each layer.Conclusion] XST can improve the retinal pathological structure of GK type 2 diabetic rats.