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Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue |
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| Authors: | Diana Bell Yi-Jue Zhao Pulivarthi H. Rao Randal S. Weber Adel K. El-Naggar |
| Affiliation: | (1) Department of Pathology, Unit 85, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA;(2) Texas Children’s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3-3320, Houston, TX 77030, USA;(3) Department of Head and Neck Surgery, Unit 0441, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA;(4) Department of Pathology and Head and Neck Surgery, Unit 85, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA |
| Abstract: | We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed. |
| Keywords: | Adenoid cystic carcinoma Cytogenetic Comparative genomic hybridizations Spectral karyotyping Translocations |
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