血浆NT-proBNP水平对重度及以上慢性阻塞性肺疾病患者肺功能的预测价值

目的探讨血浆氨基末端脑钠肽前体（NT-proBNP）水平对重度及以上慢性阻塞性肺疾病（COPD）患者肺功能的预测价值。方法 67例COPD患者根据肺功能分成中度组（35例）与重度及以上组（32例）。用电化学发光免疫分析技术（ECLIA）检测血浆中的NT-proBNP水平。两组数据间的比较采用成组t检验,相关性分析采用Spearman秩相关分析。用ROC曲线进行诊断价值的判定。结果两组患者血浆NT-proBNP水平、FEV1及FEV1%比较差异均有统计学意义（均P〈0.05）,NT-proBNP与FEV1%间存在负相关。NT-proBNP的诊断界点为1 105 pg/ml,敏感度0.906,特异度0.943,曲线下面积0.934。结论血浆NT-proBNP水平可作为预测COPD患者肺功能程度的一个有价值的指标。

Predictive Value of Plasmatic NT-proBNP Level for Lung Function of Severe and Very Severe Chronic Obstructive Pulmonary Disease Patients

Objective To investigate if NT-proBNP level in plasma can predict lung function of severe chronic obstructive pulmonary disease（COPD） patients.Methods COPD patients in hospital were recruited and divided into two groups according to lung function： the moderate group（n=35） and severe group（n=32）.NT-proBNP levels in plasma were detected by electrochemiluminescence immunoassay（ECLIA）.The different levels of NT-proBNP were compared by using t test.The correlation NT-proBNP and FEV1% were assessed by spearman correlation test.Receiver operating characteristic（ROC） curve was used to evaluate the diagnostic value of NT-proBNP.Results NT-proBNP levels,FEV1 and FEV1% in the two groups were different significantly.NT-proBNP was negatively correlated with FEV1%.ROC curve of NT-proBNP was drawn using SPSS 13.0 software,with diagnostic cut-off point： 1 105 pg/ml,sensitivity： 0.906,speciticity： 0.943,and area under curve： 0.934.Conclusion NT-proBNP level in plasma is potentially a predictive index for lung function of patients with COPD.