The additive benefits of influenza and pneumococcal vaccinations during influenza seasons among elderly persons with chronic lung disease |
| |
| Affiliation: | 1. Department of Medicine, Hutt Hospital, Hutt Valley District Health Board, High St, Lower Hutt 5010, New Zealand;2. Wellington SCL Microbiology Laboratory, Wellington Hospital, Riddiford St, Wellington 6010, New Zealand;3. Department of Infection Services, Wellington Hospital, Capital and Coast District Health Board, Riddiford St, Wellington 6010, New Zealand;1. Dept of Veterinary Public Health and Food Safety;2. National Center for Immunobiologicals Research and Evaluation, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy;3. The list of members of the RotaNet-Italy Study Group who contributed data is shown in the Appendix;1. National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam;2. Pediatric Center, Hue Central Hospital, Hue, Viet Nam;3. Hai Phong Children Hospital, Hai Phong, Viet Nam;4. Centers for Disease Control and Prevention, USA;3. ASL Alto Adige, Bolzano, Italy;4. University of Milan, Milan, Italy;5. Ospedale Maggiore, Chieri, Italy;6. Ospedale Civico, Chivasso, Italy;7. Ospedale ‘Martini’, Torino, Italy;8. Ospedale ‘San Giacomo Apostolo’, Castelfranco Veneto (TV), Italy;9. AOU – Policlinico, Modena, Italy;10. AOU – Policlinico ‘S. Orsola-Malpighi’, Bologna, Italy;11. University UNIVPM, Ancona, Italy;12. University of Perugia, Italy;13. Manuela Onori, Ospedale Pediatrico ‘Bambino Gesù’, Roma, Italy;14. Policlinico ‘A. Gemelli’, Roma, Italy;15. ASP Basilicata, Potenza, Italy;p. University of Sassari, Italy;1. Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy;2. National Center for Immunobiologicals Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy;1. Department of Family and Community Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO, USA;2. The Advanced HEAlth Data (AHEAD) Research Institute, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO, USA;3. Saint Louis University, School of Medicine, Department of Internal Medicine Division of Infectious Diseases, Allergy, and Immunology, Saint Louis, MO, USA;4. Saint Louis University, Department of Molecular Microbiology & Immunology, Saint Louis, MO, USA;5. Saint Louis University, School of Medicine, Department of Internal Medicine, Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO, USA;6. Division of Geriatric Medicine, Saint Louis University, SLUCare Academic Pavilion, Section 2500, 1008 S. Spring Ave, St. Louis, MO, USA;7. Saint Louis University School of Medicine, Family and Community Medicine, 1008 S. Spring, SLUCare Academic Pavilion, 3rd Floor, 63110, St. Louis, MO, USA;1. Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA;2. Bill & Melinda Gates Foundation, Enteric and Diarrheal Diseases, Seattle, WA, USA |
| |
| Abstract: | ![]()
Uncertainty regarding the benefits of pneumococcal vaccination may contribute to the under use of this vaccine. The present study was conducted to clarify the benefits of influenza and pneumococcal vaccinations during 3 influenza seasons among elderly persons with chronic lung disease. All elderly members of a large managed care organization with a prior diagnosis of chronic lung disease were included in a cohort that was followed over three influenza seasons (1993–1994, 1994–1995, and 1995–1996). Data obtained from the administrative data bases of the health care organization included baseline demographic and health characteristics, influenza vaccination status for each season, date of pneumococcal vaccination, and outcomes for each season including hospitalization for pneumonia and death. Cox proportional hazards regression and Poisson regression with repeated measures were used to compare the risk of outcomes among vaccinated and unvaccinated persons while controlling for covariates and confounders. During the three influenza seasons, influenza vaccination alone was associated with a 52% reduction (95% CI 18–72) in hospitalizations for pneumonia and a 70% reduction (95% CI 57–89) in death. Pneumococcal vaccination alone during the three influenza seasons was associated with a 27% reduction (95% CI 13–52) in hospitalizations for pneumonia and a 34% reduction (95% CI 6–54) in death. Both vaccinations together demonstrated additive benefits. When both vaccinations had been received, there was a 63% reduction (95% CI 29–80) in hospitalizations for pneumonia and an 81% reduction (95% CI 68–88) in death versus when neither had been received. These findings suggest pneumococcal vaccination is associated with substantial benefits for elderly persons with chronic lung disease. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
