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| 氟尿嘧啶聚乳酸微球的制备工艺及体外释药特性 | |
| 引用本文： | 邱海霞,田景振,梅兴国. 氟尿嘧啶聚乳酸微球的制备工艺及体外释药特性[J]. 中国医药工业杂志, 2006, 37(4): 245-247 |
| 作者姓名： | 邱海霞 田景振 梅兴国 |
| 作者单位： | 1. 军事医学科学院毒物药物研究所,北京,100850 2. 山东中医药大学药学院,山东,济南,250014 |
| 摘 要： | 采用溶剂挥发法制得氟尿嘧啶聚乳酸微球。以载药量及包封率为评价指标，通过正交设计优化处方。制品外观圆整，表面有细小孔隙，平均粒径为80μm，平均载药量10％，包封率为84％，体外释药用双相动力学方程拟合效果较好，释药机理为溶蚀和扩散。 |
| 关 键 词： | 氟尿嘧啶 聚乳酸 微球 体外释放 |
| 文章编号： | 1001-8255（2006）04-0245-03 |
| 收稿时间： | 2005-04-25 |
| 修稿时间： | 2005-04-25 |
Preparation and in vitro Release of Fluorouracil PLA-Microspheres |
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| QIU Hai-Xia,TIAN Jing-Zhen,MEI Xing-Guo. Preparation and in vitro Release of Fluorouracil PLA-Microspheres[J]. , 2006, 37(4): 245-247 | |
| Authors: | QIU Hai-Xia TIAN Jing-Zhen MEI Xing-Guo |
| Affiliation: | 1. Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing 100850; 2. Dept. of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250014 |
| Abstract: | The fluorouracil PLA-microspheres were prepared by solvent evaporation method. The formulation was optimized by orthogonal design using drug loading and the encapsulation efficiency as evaluation parameters. The product was spherical and had pores on surface. The average diameter was 801.tm, drug loading was 10% and encapsulation efficiency was 84%. The double phase dynamic model was the best choice for fitting the in vitro drug release profiles among several mathematical models, and the release mechanism was erosion and diffusion. |
| Keywords: | fluorouracil PLA microsphere in vitro release |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |