妊高征患者MDA SOD ET-1水平的变化

为探讨ＭＤＡ、ＳＯＤ活性及ＥＴ－１ 在妊高征发病中的作用，１９９６ 年１～１２月对在院住院分娩的妊高征患者３９例，正常晚孕妇女２４ 例，正常非孕妇女１４ 例进行血浆ＭＤＡ、ＳＯＤ活性及ＥＴ－１ 水平测定，同时测定产后３～７ 天血浆水平的变化。结果：正常晚孕组ＭＤＡ、ＳＯＤ活性及ＥＴ－１均高于非孕妇女（Ｐ＜ ０．０５）；妊高征组ＭＤＡ、ＥＴ－１高于正常晚孕组（Ｐ均＜ ０．０１），ＳＯＤ活性则低于正常晚孕组（Ｐ＜ ０．０５）；重度妊高征分娩后３～７ 天ＥＴ－１、ＭＤＡ均低于产前（Ｐ均＜ ０．０５），ＳＯＤ则高于产前（Ｐ＜ ０．０５）；ＭＤＡ、ＥＴ－１ 与平均动脉压呈正相关（ｒ＝ ０．４３９，Ｐ＜ ０．０１），ＳＯＤ活性与平均动脉压呈负相关（ｒ＝ － ０．４５３，Ｐ＜ ０．０１）。表明机体内氧化抗氧化失衡与内皮细胞损伤在妊高征发病过程中起重要作用。

Variation of Plasma Levels of MDA SOD and Endothelin 1 in Cases of Pregnancy Induced Hypertension(PIH)

To evaluate the causative role of plasma MDA,SOD and Endothelin 1 in pregnancy induced hypertension(PIH),we determined the contents of antepartum and postpartum plasma MDA,SOD and ET 1 in 39 patients with PIH(24 normal pregnant women, and 14 normal non pregnant).Results indicated that the levels of MDA,SOD and ET 1 in normal pregnant women were higher than those in non pregnant women(P<0.05),that the levels of plasma MDA, ET 1 in cases of PIH were higher than those in normal pregnant women(P<0.01),while the levels of SOD were lower(P<0.05). That the levels of antepartum plasma MDA, ET 1 were lower than those of postpartum in patients with severe PIH, and that there was a positive correlations between the mean arterial pressure and the levels of MDA, ET 1.The author concluded that the imbalance of oxidation and antioxidation and endothelial cell injury may play an important role in the pathogensis of PIH.