加德纳菌影响女性生育的实验研究

目的：探讨阴道加德纳菌对不孕不育女性患者生育的影响,分析经过系统治疗阴道加德纳菌转阴后的怀孕几率。方法：选择2010年3月至2013年4月来我院就诊的不孕不育女性患者,阴道加德纳菌涂片检查阳性并且经过系统治疗后的女性患者50例作为实验组。其中以检测阴道加德纳菌涂片检查阳性,没有接受系统治疗的50例作为阳性对照组。以同时期在孕前检查为正常健康女性,在其孕前检查时取标本,婚前检测及婚后1年中每个月来我院检查一次阴道加德纳菌为阴性者,入选50例为阴性对照组。通过免疫荧光法检测两组女性阴道分泌物的加德纳菌。结果：实验组的成功生育几率为90%（45/50）,阳性对照组的生育几率为30%（15/50）,阴性对照组的生育几率为96%（48/50）。阳性对照组与实验组比较有统计学意义P〈0.01,阴性对照组与实验组比较无统计学意义P〉0.05。结论：阴道加德纳菌对女性的生育有严重的影响。

Effects of gardnerella vaginalis on female fertility

Objectives： To explore the effect of gardnerella vaginalis on female infertility patients,and analyze their chances of pregnancy after treatment when Gardnerella vaginalis has become negative. Method： Infertility female patients that came to our hospital from March 2010 to April 2013 were selected,where 50 Gardnerella vaginalis smear- positive patients who had received systematic treatment were regarded as experimental group,50 Gardnerella vaginalis smear- positive patients who had not received systematic treatment were regarded as positive control group,and another 50 Gardnerella vaginalis smear- negative patients who was normal and healthy in the pre- pregnancy test and the monthly test after marriage for a year were regarded as negative control group. Gardnerella vaginalis in the vaginal secretions of females in the three groups were detected by immunofluorescence assay. Results： The successful fertility rates of the experimental group,positive control group and negative control group were 90%（ 45 / 50）,30%（ 15 /50） and 96%（ 48 /50） respectively. Compared with the experimental group,the positive control group was statistically significant（ P〈0. 01）,while the negative control group was not statistically significant（ P〉0. 05）. Conclusion： The Gardnerella vaginalis exerts serious impact on female fertility.