纵向研究0-2岁婴幼儿变异链球菌群与早期婴幼儿龋的关系

目的探讨8～32个月婴幼儿牙菌斑中变异链球菌群的定植情况,并分析其早期定植与龋病关系。方法收集广州市花都区新华镇225名8月龄婴幼儿,每半年复查一次,持续两年,至婴幼儿32月龄。复查内容包括龋病检查和前牙牙菌斑样本收集。WHO诊断标准用于龋病诊断,选择性培养基及生化实验用于变异链球菌群的分离鉴定。统计方法采用χ2检验或Fisher确切概率法。结果 8月、14月、20月、26月和32月龄变异链球菌群定植率分别为6.7%、31.2%、50.3%、61.0%和75.5%。其中,8月龄组有2名幼儿检出变异链球菌群未见乳牙萌出。变异链球菌群首次检出的平均年龄为（19.6±6.9）个月。婴幼儿乳牙变异链球菌群早期定植患龋率高于晚期定植,32月龄组差异有统计学意义（P=0.018）。结论变异链球菌群能在未萌牙口腔中检出,其定植率随年龄的增长而增加。变异链球菌群在前牙面的早期定植促进乳牙龋病的发生。

Longitudinal study of mutant streptococci in relation to dental caries in 8-32 month old children

Objective To explore the presence of mutant streptococci and the early colonization of mutant streptococci in relation to dental caries in 8-32 month old children.Methods Dental caries was examined and dental plaque samples were collected in 225 children of 8 month old at Xinhua Town,Huadu District of Guangzhou at baseline,and the follow-ups were conducted every 6 months until the subjects were 32 months old.The criteria recommended by World Health Organization were used for the diagnosis of dental caries.D...