电针对血管性痴呆大鼠脑组织MDA和AchE含量的影响

[目的]探讨电针对血管性痴呆大鼠脑组织丙二醛(MDA)、乙酰胆碱脂酶(AchE)含量的影响.[方法]采用改良Pusinelli(4-VO)4-血管阻断法,建立全脑缺血再灌注大鼠痴呆模型,32只SD大鼠随机分为假手术对照组、模型对照组、电针治疗组、脑复康治疗组,给予相应措施处理后.同时处死大鼠检测其大脑皮质中MDA、AchE含量变化;用Y型电迷宫进行行为学测试.经统计学处理,比较组间差异.[结果]模型对照组大鼠Y电迷宫成绩低于假手术组(P<0.05),其大脑皮质中MDA、AchE含量测值较假手术组为高(P<0.05),各治疗组Y电迷宫学习成绩优于模型组(P<0.05);大脑皮质中MDA、AchE测值低于模型组(P<0.05);且与假手术组无显著性差异(P>0.05).[结论]电针治疗可明显改善缺血性痴呆大鼠脑组织抗氧化能力.可能与减轻脑内活性氧损伤、自由基损伤反应.从而改善其学习记忆能力而产生治疗作用.

Influences of electric acupuncture on malondialdehyde and acetylcholinesterase in cerebral tissues of rats with vascular demention

[Objective] To explore the effect of electric acupuncture on the level of malondialdehyde, acetylcholinesterase in cerebral tissues in rats with demention. [Methods] Vascular dementia in rat was established by reperfusion following cerebral global ischemia using a modified Pulsinelli-4-vessel occlusion method. Thirty-two rats were randomly divided into 4 groups : sham-operated control group, mod- el group, electroacupuncture group, Piracetan group. They were treated with electroacupuncture, Piracetan, respe...