| 高效液相色谱法测定雷贝拉唑钠血药浓度 |
| |
| 引用本文： | 郭利民,钟世华.高效液相色谱法测定雷贝拉唑钠血药浓度[J].中国医药导报,2008,5(3):29-30. |
| |
| 作者姓名： | 郭利民 钟世华 |
| |
| 作者单位： | 1. 湖南省益阳市中心医院药剂科,湖南益阳,413000
2. 湖南师范大学化工学院,湖南长沙,410081 |
| |
| 摘 要： | 目的：建立测定雷贝拉唑钠血药浓度的高效液相色谱法。方法：采用Hypersil C18柱（4.6mm×200mm,5μm）,以乙腈-水（32∶68）为流动相,流速1.0ml/min,检测波长288nm。结果：本方法线性范围5～1600μg/L,r=0.9993,回收率为95.48%～99.13%。日内及日间RSD均小于4%。结论：本方法灵敏、准确、重现性好,适用于雷贝拉唑钠药代动力学研究。
|
| 关 键 词： | 雷贝拉唑钠 血药浓度 高效液相色谱法 |
| 文章编号： | 1673-7210(2008)01(c)-029-02 |
| 修稿时间： | 2007年11月7日 |
Determination of rabeprazole sodium in serum by HPLC |
| |
| GUO Li-min,ZHONG Shi-hua.Determination of rabeprazole sodium in serum by HPLC[J].China Medical Herald,2008,5(3):29-30. |
| |
| Authors: | GUO Li-min ZHONG Shi-hua |
| |
| Institution: | GUO Li-min1,ZHONG Shi-hua2* |
| |
| Abstract: | Objective：To set up a reverse phase HPLC method for determining the concentration of rabeprazole sodium in serum in order to study its clinical pharmacokinetics.Methods：The chromatographic separation was carried out on Hypersil C18 column（4.6 mm×200 mm,5 μm）, the mobile phase was acetonitrile-water（32：68） and flow rate was 1.0 ml/min. The detector wavelength was 288 nm.Results：The linear range was 5-1 600 μg/L, r=0.999 3. The method recovery was within 95.48%-99,13%,within-day and between-day R SD were less than 4%.Conclusion ：The method is sensitive, specific and reproducible for the determination of rabeprazole sodium concentration in humam plasma.It is very suitable for pharmacokinetics study of rabeprazole sodium. |
| |
| Keywords: | Rabeprazole sodium Plasmn concentration HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
