Prevention and treatment of acute renal failure: An experimental study |
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| Affiliation: | 1. Department of Cardiology, Blekinge Hospital, Karlskrona, Sweden;2. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;3. Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden;4. Department of Cardiothoracic Anaesthesia and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden;5. Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden;6. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden;7. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden;1. The Faculty of Computer Science and Engineering, Xi’an University of Technology, Xi’an 710048, China;2. The Engineering College, Honghe University, Mengzi 661199, China |
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| Abstract: | - 1.1. Experimental renal failure has been produced in seventy-six dogs by a combination of operation (right nephrectomy), ischemia, and the administration of acid hematin solution. Mannitol, low molecular weight dextran, THAM, and 5 per cent dextrose in water have been compared regarding their relative effectiveness in preventing or prolonging survival after the induction of renal failure.
- 2.2. Mannitol, low molecular weight dextran, and the organic buffer THAM, in the experimental setting of this study, did not appear to be more beneficial than 5 per cent dextrose in water in preventing or prolonging survival after the induction of acute renal failure. Extensive petechial hemorrhages involving the mesentery and serosa of the bowel were frequently observed in animals receiving low molecular weight dextran.
- 3.3. Control groups (animals receiving 5 per cent dextrose in water solution) consistently had the most seven day survivors as well as the longest mean survival times of any of the groups studied.
- 4.4. The beneficial effect of adequate hydration prior to the performance of diagnostic procedures or operations known to be associated with renal damage is emphasized.
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