低温等离子体活化处理骨修复材料的组织学研究

目的为提高植入材料的生物活性，研究植入材料对机体组织产生的生物效应。方法采用低温等离子表面活化处理技术，将羟基磷灰石颗粒置于真空高压电场中，通入ＮＨ３、Ｈ２、Ｎ２混合气体，在电容耦合辉光放电的等离子体环境中，使材料表面瞬间获得活性氨基结构。再通过动物骨内埋植实验，按不同时期对材料—骨界面的变化作动态组织学观察。结果材料经表面活性处理后，其表面获得新生活性基团，而对材料本体的形态和性能不产生任何影响，植入骨内后能使材料—骨界面早期形成新骨并具有明显的促进骨生长作用，达到骨性结合的目的。结论低温等离子体活化处理是提高植入材料生物活性的一种有效途径和方法

Histomorphologic study of the bone repair materials by using the cold plasma technique

Objective The purpose of this article is to improve the biological activity of the implant pretreated by use of cold plasma technic and to investigate the biological effects after implanted into bone.Methods First, HA granular was set in the electric field with high voltage and vacuum, then the gaseous mixture of ammonia, hydrogen and nitrogen was led to. By coupled capacity glow discharge, the plasma was produced and the pretreatment was completed. In this way, the surface of HA granular may obtain active amino structure. Sequently, the material was implanted into bone of the animal and the dynamic changes at the material/bone interface were histologically observed. Results The active group was definitely formed on the surface of the material after pretreatment and there were no adverse effects on the morphology and properties of the base material . Furthermore, the early formation of new bone at the interface of the material/bone was detected, and obvious effects on facilitating bone growth and osseointegration were obtained. Conclusion The findings indicated that cold plasma pretreatment technic was an effective method to improve the biological activity of implant material.