脑血管病脂蛋白（a）和其它脂类水平的研究

目的：探讨脑血管病患者脂脂蛋白（a)[Lp(a)]和其它脂类水平与脑血管病的关系。方法：采用试剂盒检测55例脑出血，57例脑梗塞患者Lp(a)水平及胆固醇（Ch)、甘三酯（TG）、高密度脂蛋白（HDL）、载脂蛋白A－I（Apo-A-I)和载脂蛋白B（ApoB)，并与85例健康对照者作比较，结果：脑梗塞组Lp(a),Apo(B)及TG呈显著正相关，而脑出血组Lp(a)与Ch呈显著负相关，脑梗塞组Lp(a)、TG异常检出率分别高达59．65％、52．63％，脑出血组HDL异常检出率高达50．91％，结论Lp(a)和其它脂类代谢异常是脑血管病患者最常见和重要的致病因素之一。

A Study on Levels ofLipoprotein(a) and Other Lipids in Patients with Cerebrovascular Diseases

Objective To study the relationship between the changes of lipoprotein(a), other lipids and cerebrovascular diseases. Methods The serum levels of lipoprotein(a)〔Lp(a)〕apolipoprotein A-I (Apo A-I),apolipoprotein B(Apo B),cholesterol (Ch), triglyceride (TG) and high density lipoprotein cholesterol (HDL) were determined in 55 patients with cerebral infarction, 57 patients with cerebral hemorrhage and in 85 healthy controls by reagent kit. Results It was found that patients with cerebral infarction had significantly higher levels of Lp(a), Aop B and TG, and lower level of HDL.Patients with cerebral hemorrhage had significantly higher levels of Lp(a), Apo B, TG, and lower level of Ch than controls did. There was a significantly positive correlation between Lp(a) and TG in patients with cerebral infarction,while a significantly negative correlation between Lp(a) and Ch in patients with cerebral hemorrhage. The detective rates of abnormal Lp(a) and TG in cerebral infarction were as high as 59.65% and 52.63% respectively. The detective rate of abnormal HDL in cerebral hemorrhage was as high as 50.91%. Conclusion It is suggested that the abnormal Lp(a) and other lipids are one of the most common and important risk factors for cerebrovascular diseases.