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| 锰的神经毒性及其机制研究进展 | |
| 引用本文： | 颜伟,王克跃. 锰的神经毒性及其机制研究进展[J]. 微量元素与健康研究, 2009, 26(3) |
| 作者姓名： | 颜伟 王克跃 |
| 作者单位： | 遵义医学院预防医学教研室,贵州,遵义,563003 |
| 基金项目： | 遵义医学院博士启动资金 |
| 摘 要： | 锰是人体的一种必需微量元素,具有非常重要的生理功能,但过量摄入则会对人体造成损害,主要表现为神经精神系统的慢性毒性作用,以类帕金森综合症的椎体外系神经损害为特征。锰中毒的主要机理涉及神经细胞凋亡、神经递质代谢紊乱、突触传导功能障碍,亦与基因易感性和遗传多态性有关。 |
| 关 键 词： | 锰 神经毒性 作用机制 |
Progress of Manganese Neurotoxicity and Its Mechanism |
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| YAN Wei,WANG Ke-yue. Progress of Manganese Neurotoxicity and Its Mechanism[J]. Studies of Trace Elements and Health, 2009, 26(3) | |
| Authors: | YAN Wei WANG Ke-yue |
| Affiliation: | YAN Wei; WANG Ke-yue(Department of Preventive Medicine Zunyi Medical College; Guizhou Zunyi 563003; China); |
| Abstract: | Manganese is an essential trace element and has very important physiological functions to the human body.However,it will result in harmful effects on the human body when it is taken excessively.Manganese poisoning mainly manifests chronic Neurotoxicity like Parkinson's disease because of extrapyramidal nerve damage.The mechanisms of manganese poisoning are concerned with nerve cell apoptosis,neurotransmitter metabolic disorders,conduction synaptic dysfunction,and genetic susceptibility and genetic polymorph... |
| Keywords: | Manganese poisoning Neurotoxicity Mechanism |
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