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| INDEPENDENT AND SYNERGIC INHIBITION OF DIPYRIDAMOLE AND RADIATION ON K562-AND K562/ADM CELL LINES IN VITRO | |
| 引用本文： | 谢佐福,沈世仁. INDEPENDENT AND SYNERGIC INHIBITION OF DIPYRIDAMOLE AND RADIATION ON K562-AND K562/ADM CELL LINES IN VITRO[J]. 中国癌症研究, 1992, 4(3): 31-35. DOI: 10.1007/BF02997215 |
| 作者姓名： | 谢佐福 沈世仁 |
| 作者单位： | Department of Radiebiology，Tumor Research Institute，Fujian Provincial Tumor Hospital. Fuzhou，Department of Radiebiology，Tumor Research Institute，Fujian Provincial Tumor Hospital. Fuzhou |
| 摘 要： | It is first demonstrated that dipyridamole (DP) and radiation were capable of significantly inhibiting, independently and synerglcally, clonogenlc growth in the two kinds of K562 cell lines, adriamycin (ADM) -sensitive and ADM- resistant. DP or radiation alone Increased clonogenlc Inhibition rate (CIR) in the two kinds of cell lines in a dose- dependent fashion. DP potentiated radiosensitivity and radiation increased inhibition of DP in the two kinds of cell lines. K562/ ADM cell lines were higher sensitive to DP. radiation and combination of them than K562 cell lines (P<0. 01). There was stronger synergic inhibition of clonogenlc growth in the two kinds of cell lines when pretreated with DP than when posttreated with DP (P<0. 01). |
Independent and synergic inhibition of dipyridamole and radiation on K562-and K562/ADM cell linesin vitro |
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| Zuofu Xie,Shiren Shen. Independent and synergic inhibition of dipyridamole and radiation on K562-and K562/ADM cell linesin vitro[J]. Chinese Journal of Cancer Research, 1992, 4(3): 31-35. DOI: 10.1007/BF02997215 | |
| Authors: | Zuofu Xie Shiren Shen |
| Affiliation: | Xie Zuofu Shen ShirenDepartment of Radiebiology,Tumor Research Institute,Fujian Provincial Tumor Hospital. Fuzhou |
| Abstract: | It is first demonstrated that dipyridamole (DP) and radiation were capable of significantly inhibiting, independently and synerglcally, clonogenlc growth in the two kinds of K562 cell lines, adriamycin (ADM) -sensitive and ADM- resistant. DP or radiation alone Increased clonogenlc Inhibition rate (CIR) in the two kinds of cell lines in a dose- dependent fashion. DP potentiated radiosensitivity and radiation increased inhibition of DP in the two kinds of cell lines. K562/ ADM cell lines were higher sensitive to DP. radiation and combination of them than K562 cell lines (P<0. 01). There was stronger synergic inhibition of clonogenlc growth in the two kinds of cell lines when pretreated with DP than when posttreated with DP (P<0. 01). |
| Keywords: | dipyridamole. radiation. K562 cell line. K562/ADM cell line. |
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