| 双氯灭痛药膜体外透皮速率的实验研究 |
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| 引用本文： | 马晓微,梁文权.双氯灭痛药膜体外透皮速率的实验研究[J].浙江大学学报(医学版),1995(3). |
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| 作者姓名： | 马晓微 梁文权 |
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| 作者单位： | 浙江医科大学药学系药剂教研室 |
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| 摘 要： | 作者选择乙基纤维素、聚乙烯醇等高分子材料制成涂膜剂，用大鼠皮进行双氯灭痛药膜的体外透皮速率测定。结果表明，氮酮与丙二醇可以促进药物渗透。不同的高分子材料可影响药物的扩散与释放，从而影响其透皮速率。与无膜无促透剂处方相比，药物在乙基纤维素中的透皮速率没有增加，在聚乙烯醇膜中的透皮速率有显著增加。
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| 关 键 词： | 双氯灭痛／投药和剂量 皮肤吸收 透皮速率 皮肤 大鼠 |
STUDIES ON IN-VITRO PERCUTANEOUSPENETRATION OF SODIUM DICLOFENAC PIGMENT |
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| Ma Xiaowei and Liang Wenquan.STUDIES ON IN-VITRO PERCUTANEOUSPENETRATION OF SODIUM DICLOFENAC PIGMENT[J].Journal of Zhejiang University(Medical Sciences),1995(3). |
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| Authors: | Ma Xiaowei and Liang Wenquan |
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| Abstract: | Sodium diclofenac(DS)pigment was prepared by using ethylcellulose and polyvinyl alcohol.The percutaneous penetration rate of DS through rat skin was measured in vitro by using modified Franz diffusion cell.The results showed that azone and propylene glycol increased the skin permeability of DS,and various polymers affected the release and percutaneous penetration rate of DS in the pigment.In comparison with the formulated vehicle without the polymer and the penetration enhancers.the percutaneous penetration rate of DS from ethylcellulose were not increased, while the increasing magnitude in the percutaneous penetration rate from polyvinyl alcohol was very significant. |
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| Keywords: | Sodium Diclofenac/admin Skin absorption Percutaneous Rate Skin rats |
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