| IL-21在Th17细胞炎症反应中的作用 |
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| 引用本文： | 刘巍,田文单,Sally A.Huber. IL-21在Th17细胞炎症反应中的作用[J]. 国际免疫学杂志, 2011, 34(4): 274-276. DOI: 10.3760/cma.j.issn.1673-4394.2011.04.008 |
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| 作者姓名： | 刘巍 田文单 Sally A.Huber |
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| 作者单位： | 1. 哈尔滨医科大学附属第一医院心内科,150001
2. University of Vermont,Burlington,05401 |
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| 基金项目： | 国家自然科学基金青年基金 |
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| 摘 要： | Th17细胞是新近发现的T淋巴细胞亚群.作为不同于Th1、Th2的细胞亚群,已经被证实在自身免疫病、感染、炎症等疾病中发挥重要作用.IL-21作为Th17细胞的自分泌调节因子,在Th17细胞功能的维持、抑制Th1、调节性T细胞(Treg)分化等方面发挥关键作用.Th17细胞能够自分泌产生IL-21,从而促进自身分化过程...
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| 关 键 词： | Th17细胞 IL-21 TGF-β |
Effects of IL-21 in Th17 cell maintenance |
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| LIU Wei,TIAN Wen-dan,Sally A.Huber. Effects of IL-21 in Th17 cell maintenance[J]. International Journal of Immunology, 2011, 34(4): 274-276. DOI: 10.3760/cma.j.issn.1673-4394.2011.04.008 |
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| Authors: | LIU Wei TIAN Wen-dan Sally A.Huber |
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| Affiliation: | LIU Wei , TIAN Wen-dan, Sally A. Huber. Department of cardiodiology , The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China |
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| Abstract: | Th17 cell has recently been identified as an IL-17-producing CD4+ Th cell, and its functions and regulatory mechanisms in immune responses have been studied extensively. Functional studies have provided evidence that Th17 cells are important for the modulation of autoimmune responses and inflammation.Murine Th17 cell differentiation is promoted by the coordinated functions of distinct cytokines including TGFp,IL-6,IL-21 and IL-23, whereas IL-2,IL-4,IFNγ and IL-27 inhibit Th17 cell differentiation. Th17 cell could produce IL-21 ,thus promotes auto-differentiation. IL-21 is the new target in Th17 cell-mediated diseases. |
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| Keywords: | IL-21 |
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