氨溴特罗口服液治疗儿童肺炎支原体肺炎的临床观察

目的 观察氨溴特罗口服液治疗肺炎支原体肺炎的临床疗效.方法 106例哮喘患儿随机分为观察组52例和对照组54例,在静脉滴注红霉素的基础上观察组给予氨溴特罗口服液,对照组给予盐酸氨溴索糖浆.结果 观察组痊愈12例,有效16例,无效6例,总有效率88.5%(46例),对照组痊愈9例,显效17例,有效17例,总有效率79.6%(43例).观察组总有效率明显高于对照组,差异有统计学意义(X2=3.41,P＜0.01).观察组咳嗽、啰音消失时间、低氧血症纠正时间及住院天数较对照组明显缩短[分别为(10.3±3.6)d比(15.8±4.6)d、(3.8±1.9)d比(5.2±2.1)d、(2.5±0.7)d比(3.9±0.9)d、(10.8±4.8)d比(14.5±4.8)d,均P＜0.01].观察组治疗后较治疗前用力肺活量、第1秒用力呼气量、呼气流量峰值、25%肺活量最大呼气流量和50%肺活量最大呼气流量明显改善,气道反应性明显减轻,差异均有统计学意义(P＜0.01).结论 氨溴特罗口服液能有效控制症状,降低气道高反应性,改善肺功能.

Abstract：

Objective To discuss the clinical efficacy of ambroxol hydrochloride and clenbuterol hydrochloride oral solution for children with mycoplasma pneumonia. Methods Totally 106 cases of children with mycoplasma pneumonia were randomly divided into observation group and control group. Based on erythromycin, the observation group used ambroxol hydrochloride and clenbuterol hydrochloride oral solution and the control group used the ambroxol. Results The total efficacy of observation group was higher than that of control group. Cough, rales disappearance time, hypoxemia recovery time and length of hospital stay in observation group were significantly shorter than those in the control group[(10.3±3.6)d vs (15.8±4.6)d, (3.8±1.9)d vs (5.2±2.1)d, (2.5±0.7)d vs (3.9±0.9)d,(10. 8 ±4.8)d vs (14.5 ±4. 8)d, P＜0.01]. Pulmonary function parameters of forced vital capacity, forced expiratory volume in first second, peak expiratory flow, maximal expiratory flow in 25% vital capacity (MEF25)and MEF50 were significantly decreased in observation group compared with control group (P＜0. 01). Conclusion Ambroxol hydrochloride and clenbuterol hydrochloride oral solution can effectively control the symptoms, decrease degrade airway hyperresponsiveness and improve lung function.

Curative effect of ambroxol hydrochloride and clenbuterol hydrochloride oral solution in mycoplasma pneumonia children

Objective To discuss the clinical efficacy of ambroxol hydrochloride and clenbuterol hydrochloride oral solution for children with mycoplasma pneumonia. Methods Totally 106 cases of children with mycoplasma pneumonia were randomly divided into observation group and control group. Based on erythromycin, the observation group used ambroxol hydrochloride and clenbuterol hydrochloride oral solution and the control group used the ambroxol. Results The total efficacy of observation group was higher than that of control group. Cough, rales disappearance time, hypoxemia recovery time and length of hospital stay in observation group were significantly shorter than those in the control group[(10.3±3.6)d vs (15.8±4.6)d, (3.8±1.9)d vs (5.2±2.1)d, (2.5±0.7)d vs (3.9±0.9)d,(10. 8 ±4.8)d vs (14.5 ±4. 8)d, P＜0.01]. Pulmonary function parameters of forced vital capacity, forced expiratory volume in first second, peak expiratory flow, maximal expiratory flow in 25% vital capacity (MEF25)and MEF50 were significantly decreased in observation group compared with control group (P＜0. 01). Conclusion Ambroxol hydrochloride and clenbuterol hydrochloride oral solution can effectively control the symptoms, decrease degrade airway hyperresponsiveness and improve lung function.