| Wnt信号通路与骨肉瘤 |
| |
| 引用本文： | 陶可,熊奡,曾晖.Wnt信号通路与骨肉瘤[J].国际肿瘤学杂志,2011,38(7):551-554. |
| |
| 作者姓名： | 陶可 熊奡 曾晖 |
| |
| 作者单位： | 北京大学深圳医院骨关节科,深圳,518036 |
| |
| 摘 要： | Wnt信号通路在骨骼发育中扮演重要角色,并通过多种途径影响骨肉瘤(OS)细胞株的增殖、凋亡和浸润转移.近年来,wnt信号通路在OS细胞株、OS模型和作为OS诊断和预后判定标志物作用的实验证据表明,Wnt信号通路在OS发生、进展和浸润转移中发挥关键作用,而且靶向Wnt通路治疗OS的策略及安令性评价也正在进行.探讨Wnt信...
|
| 关 键 词： | 骨肉瘤 Wnt信号通路 |
Wnt signaling pathway and osteosarcoma |
| |
| TAO Ke,XIONG Ao,ZENG Hui.Wnt signaling pathway and osteosarcoma[J].Journal of International Oncology,2011,38(7):551-554. |
| |
| Authors: | TAO Ke XIONG Ao ZENG Hui |
| |
| Abstract: | The Wnt pathway plays a crucial role in skeletal development and is indispensable for determination of OS cell lines. In recent years, experimental evidences on Wnt signaling pathway in OS cell lines and OS animal models, and that of Wnt signaling pathway as a diagnosis and prognosis marker of OS suggested that Wnt signaling pathway plays an important role in the progression, invasion and metastasis of OS. In addition, the strategy and safety evaluation to target Wnt to treat OS are underway. Exploring the significant role of Wnt signaling pathway in OS may aid in personalizing therapeutics to increase patient survival. |
| |
| Keywords: | Osteosarcoma Wnt signaling pathway |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《国际肿瘤学杂志》浏览原始摘要信息 |
| 点击此处可从《国际肿瘤学杂志》下载免费的PDF全文 |
|
