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| 人参叶中人参二醇组皂苷降解转化为人参皂苷Rg_3和Rh_2的工艺考察 | |
| 引用本文： | 单舒筠,王立波,高慧媛,黄 健,吴立军,张振秋. 人参叶中人参二醇组皂苷降解转化为人参皂苷Rg_3和Rh_2的工艺考察[J]. 沈阳药科大学学报, 2009, 26(9): 731-735 |
| 作者姓名： | 单舒筠 王立波 高慧媛 黄 健 吴立军 张振秋 |
| 作者单位： | 1 .辽宁中医药大学 药学系，辽宁 大连 116600; 2. 沈阳药科大学 中药学院，辽宁 沈阳 110016 |
| 摘 要： | 目的研究人参叶中人参二醇组皂苷降解转化为人参皂苷Rg3、Rh2的最佳工艺,以适应工业化生产的需要。方法用均匀设计法优化降解工艺条件,采用HPLC法测定人参皂苷Rg3、Rh2的含量。结果最佳降解工艺条件为体积分数60%的乙酸、55℃降解1 h。结论该工艺合理、可行,适用于工业化大生产。 |
| 关 键 词： | 人参叶 均匀设计 降解转化 人参皂苷Rg3 人参皂苷Rh2 |
| 收稿时间： | 2008-10-20 |
| 修稿时间： | 2008-11-20 |
Degradation technology of panoxadiol saponins in Folium Ginseng (leaf of Panax ginseng C.A.Mey.) to ginsenoside Rg3 and Rh2 |
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| SHAN Shu-jun,WANG Li-bo,GAO Hui-yuan,HUANG Jian,WU Li-jun,ZHANG Zhen-qiu. Degradation technology of panoxadiol saponins in Folium Ginseng (leaf of Panax ginseng C.A.Mey.) to ginsenoside Rg3 and Rh2[J]. Journal of Shenyang Pharmaceutical University, 2009, 26(9): 731-735 | |
| Authors: | SHAN Shu-jun WANG Li-bo GAO Hui-yuan HUANG Jian WU Li-jun ZHANG Zhen-qiu |
| Affiliation: | 1.Department of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600，China；2. School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University, Shenyang 110016, China |
| Abstract: | Objective To study the optimum degradation process of panoxadiol saponins in Folium Ginseng (leaf of Panax ginseng C.A.Mey.) to ginsenoside Rg3, Rh2. Method The HPLC assay method was established to determine the contents of Rg3, Rh2. The degradation process was optimized by the uniform design. Results The optimum degradation process conditions were 60 % acetic acid（V:V）, degradation temperature was 55 ℃, degradation time was 1 h. Conclusion The process is reasonable, feasible and applicable to large industrial production. |
| Keywords: | Folium Ginseng；uniform design；degradation transformation；ginsenoside Rg3；ginsenoside Rh2 |
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