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| 地喹氯铵合成工艺的研究 | |
| 引用本文： | 朱景申,黄蓉,李潮海. 地喹氯铵合成工艺的研究[J]. 中国药师, 2000, 3(2): 73-74 |
| 作者姓名： | 朱景申 黄蓉 李潮海 |
| 作者单位： | 同济医科大药学院，同济医科大药学院，同济医科大药学院，同济医科大药学院 武汉 430030，武汉 430030，武汉 430030，武汉 430030 |
| 摘 要： | 考察了地喹氯铵的合成工艺。通过对４－羟基喹哪啶的合成条件进行分析比较，发现当投料比为１：１．２，反应时间为９ｍｉｎ左右时，产率较高。在４－羟基喹哪氯化 ，加入适量的三乙胺作为缚酸剂 可提高产率。经过工艺合成的４－羟喹哪啶的收率以苯胺计算达５８．８％（文献值为４５％）。从而提高了克菌定的总收率。 |
| 关 键 词： | 合成工艺 地喹氯铵 总收率 产率 |
| 修稿时间： | 1999-07-14 |
Study onSynthetic Technique of Dequalinium Chloride |
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| Zhu Jingshen,Huang Rong,Li Chaohai,Xiong Youling Pharmacy College,Tongji Medical University,Wuhan,P.R.China. Study onSynthetic Technique of Dequalinium Chloride[J]. China Pharmacist, 2000, 3(2): 73-74 | |
| Authors: | Zhu Jingshen Huang Rong Li Chaohai Xiong Youling Pharmacy College Tongji Medical University Wuhan P.R.China |
| Affiliation: | Zhu Jingshen,Huang Rong,Li Chaohai,Xiong Youling Pharmacy College,Tongji Medical University,Wuhan 430030,P.R.China |
| Abstract: | The synthesis technique of dequalinium was explored. We found that the higher yield was obtained when the portion of materials was 1:1.2 and the reaction time was 9 min or so by the analysis and compare amony the different synthetic conditions of 4-hydroxyquinaldine. In the chlorination reaction of 4-hydroxyquinaldine, the yield could be also raised when the adequate triethylamine was added. The recovery had been reached 58.8 % (reference 45 %). Then, the total recovery of dequalinium chloride was raised. |
| Keywords: | Dequalinium chloride Technique synthesis |
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