| 胃癌病人外周血XPD751基因多态性与奥沙利铂化疗敏感性的关系 |
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| 引用本文： | 孙莹莹,梁军,袁胜利,张迎,姜健,宋珊爱,李青芳. 胃癌病人外周血XPD751基因多态性与奥沙利铂化疗敏感性的关系[J]. 齐鲁医学杂志, 2010, 25(2): 112-114. DOI: 10.3969/j.issn.1008-0341.2010.02.007 |
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| 作者姓名： | 孙莹莹 梁军 袁胜利 张迎 姜健 宋珊爱 李青芳 |
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| 作者单位： | 青岛大学医学院附属医院肿瘤科,山东,青岛,266021 |
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| 摘 要： | 目的探讨胃癌病人外周血白细胞中DNA修复基因XPD751基因多态性与奥沙利铂化疗效果的关系。方法收集经病理学检查确诊的胃癌128例，所有病例化疗前取静脉血，提取白细胞DNA，用TaqMan-MGB探针等位基因分型技术检测XPD751基因型。比较其基因型与接受奥沙利铂化疗病人临床疗效的关系。结果在128例胃癌病人中，XPD751A／A、A／C和C／C基因型分别为104（81．3％）、23（17．9％）和1例（0．8％）。经化疗后，63例病人有效，总有效率为49．2％。XPD751A／A、A／C＋C／C基因型有效率分别为53．3％（56／105）、30．4％（7／23），两者相比差异有统计学意义（χ^2=3．958，P（O．05）。携带A／A基因型病人的腹泻程度高于A／C＋C／C基因型病人（χ^2=7．212，P〈O．05）。结论XPD751基因多态性可能与胃癌对奥沙利铂为基础的化疗敏感性相关。
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| 关 键 词： | 胃肿瘤 XPD基因 多态性 单核苷酸 奥沙利铂 |
THE RELATIONSHIP BETWEEN GENETIC POLYMORPHISM OF XPD751 AND SENSITIVITY TO OXALIPLATIN-BASED CHEMOTHERAPY IN PATIENTS WITH GASTRIC CANCER |
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| SUN YING-YING,LIANG JUN,YUAN SHENG-LI,et al. THE RELATIONSHIP BETWEEN GENETIC POLYMORPHISM OF XPD751 AND SENSITIVITY TO OXALIPLATIN-BASED CHEMOTHERAPY IN PATIENTS WITH GASTRIC CANCER[J]. Medical Journal of Qilu, 2010, 25(2): 112-114. DOI: 10.3969/j.issn.1008-0341.2010.02.007 |
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| Authors: | SUN YING-YING LIANG JUN YUAN SHENG-LI et al |
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| Affiliation: | SUN YING-YING,LIANG JUN,YUAN SHENG-LI,et al(Department of Oncology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266021,China) |
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| Abstract: | Objective To investigate the relationship between genetic polymorphism of peripheral blood monocytic cell(PBMC) DNA repair gene XPD751 and therapeutic effect of oxaliplatin-based chemotherapy in patients with gastric cancer.Methods A total of 128 patients with gastric cancer were recruited for the study.PBMC DNA was abstracted from venous blood obtained from patients before chemotherapy,and XPD751 genotypes were detected with TaqMan-MGB probes. Results Of the 128 cases,the frequencies of XPD751 A/A,A/C and ... |
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| Keywords: | stomach neoplasms XPD gene polymorphism single nucleotide oxaliplatin |
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