| Glucocorticoids and prostate cancer treatment： friend or foe？ |
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| 作者姓名： | Bruce Montgomery ;Heather H Cheng ;James Drechsler ;Elahe A Mostaghel |
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| 作者单位： | [1]Department of Medicine, University of Washington, Seattle; [2]Seattle Cancer Care Alliance, Seattle; [3]Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. |
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| 摘 要： | Glucocorticoids have been used in the treatment of prostate cancer to slow disease progression, improve pain control and offset side effects of chemo- and hormonal therapy. However, they may also have the potential to drive prostate cancer growth via mutated androgen receptors or glucocorticoid receptors （GRs）. In this review we examine historical and contemporary use of glucocorticoids in the treatment of prostate cancer, review potential mechanisms by which they may inhibit or drive prostate cancer growth, and describe potential means of defining their contribution to the biology of prostate cancer.
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| 关 键 词： | 糖皮质激素受体 前列腺癌 激素治疗 雄激素受体 副作用 偏移量 GRS 生物学 |
| 收稿时间： | 2013 Oct 29 |
Glucocorticoids and prostate cancer treatment： friend or foe？ |
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| Bruce Montgomery,;Heather H Cheng,;James Drechsler,;Elahe A Mostaghel.Glucocorticoids and prostate cancer treatment： friend or foe？[J].Asian Journal of Andrology,2014,16(3):354-358. |
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| Authors: | 《Asian Journal of Andrology》 |
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| Institution: | 1.Department of Medicine, University of Washington, Seattle, Washington, USA;2.Seattle Cancer Care Alliance, Seattle, Washington, USA;3.Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA |
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| Abstract: | Glucocorticoids have been used in the treatment of prostate cancer to slow disease progression, improve pain control and offset side effects of chemo- and hormonal therapy. However, they may also have the potential to drive prostate cancer growth via mutated androgen receptors or glucocorticoid receptors (GRs). In this review we examine historical and contemporary use of glucocorticoids in the treatment of prostate cancer, review potential mechanisms by which they may inhibit or drive prostate cancer growth, and describe potential means of defining their contribution to the biology of prostate cancer. |
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| Keywords: | androgen receptor dihydrotestosterone glucocorticoid receptor glucocorticoids prostate cancer steroids testosterone |
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