自固化磷酸钙骨水泥修复牙种植体周围骨缺损实验研究

目的:本研究旨在应用国产自固化磷酸钙骨水泥修复牙种植体骨缺损的动物实验研究,观察磷酸钙骨水泥引导骨再生的方式,为将来磷酸钙骨水泥能修复牙种植体周围骨缺损奠定实验基础。方法:选取40只日本大耳白兔,在白兔右侧股骨大转子区植入BLB种植体(Φ=3.3 mm,L=8.0 mm),同时种植体冠部制造宽度为2.0 mm、深度为4.0 mm的环行骨缺损,骨缺损区充填CPC进行修复。实验组术后1、2、4、6个月随机处死大白兔10只,对骨缺损区X线骨密度分析,带种植体的硬组织磨片的组织学观察新骨的生成量,并进行统计学分析。结果:实验组磷酸钙骨水泥随时间延长而逐渐发生降解,新生骨组织沿降解裂隙长入,与种植体发生直接的接触,统计学分析结果表明各个月内的新骨量有显著性差别。结论:表明磷酸钙骨水泥在修复牙种植体周围骨缺损中展示了较好的引导骨再生性质。

Experimental Study on Self-setting Calcium Phosphate Cement in Repairing the Bone Defect of Dental Implant

Objective: The purpose of this study is to use CPC to treat bone defect of dental implant at animal experiment models and to investigate the new bone formation.Methods: 40 Japanese-Long-Ear rabbits were selected for this experiment.In the great trochanter region of the femurs of rabbits,a circumferential defects(7.3mm in diameter,4.0mm in depth) were made.At the central of the defects,BLB dental fixtures(HA coating,3.3mm in diameter 8.0mm in length) were implanted.The surrounding defects were repaired with CPC.After 1,2,4,6 months,10 rabbits were sacrificed respectively.The specimen were processed by X-ray bone density analysis,then sectioned and methyl blue stained.The histological images were imported into CMIAS.The volume of neogenetic bone was analysed by CMIAS.Results: CPC was degradated with time.Direct contact between new bone and HA coating occurred.Statistical analysis showed that the volume of new bone in each experiment group had significant difference.Conclusion: CPC expresses a good inorganic osseoconductive property.