紫草剂量与用药时间对药物流产临床效果的影响

本文对药物流产时在不同时间加用不同剂量的紫草对药物流产效果的影响进行探索。紫草的加用时间为米索前列醇 (简称米索 )应用前 3d、后 3d及前后共 6 d,剂量分别为 5 0 g、75 g和 1 0 0 g。 1 35 0例早孕妇女分成 9个研究组进行观察。结果表明 :在米索应用前 3d和前后 6 d加用紫草效果较米索应用后 3d加用紫草在完全流产率和出血时间两方面效果明显改善 (P均 <0 .0 5 )。紫草用量 5 0～ 1 0 0 g时流产效果与紫草剂量无明显相关。因此我们认为药物流产时在应用米索前紫草与米非司酮同时应用效果较好 ,剂量以5 0 g较为合理

Clinical Effects of Lithospermum Ruderale Dosage and Using-time on Medicinal Abortion Induced by Mifepristone and Misoprostol

The clinical effects of dosage and using time of Lithospermum Ruderale extract-a kind of Chinese traditional herbal medicine-on medicinal abortion induced by mifepristone and misoprostol were studied. Lithospermum Ruderale extract was administrated 3 d before, 3 d after or 3 d before plus 3 d after the administration of misoprostol respectively. The dose of Lithospermum Ruderale extract was 50 g, 75 g or 100 g respectively which was taken at once. Thus 1 350 women of early pregnancy were grouped into 9 groups and observed. The results showed that the effects of Lithospermum Ruderale used 3 d before, and 3 d before plus 3 d after (6 days) misoprostol were significantly better than only used 3 d after misoprostol both in complete abortion rate and in bleeding period( P <0.05). The dosage between 50 g and 100 g made no significant difference in clinical effects. Therefore we think that it is reasonable to used 50 g Lithospermum Ruderale before misoprostol to improve medicinal abortion.