盐酸氟西汀对血管性痴呆患者疗效的影响

目的观察盐酸氟西汀对血管性痴呆患者疗效的影响.方法将63例血管性痴呆患者随机分为两组,治疗组给予盐酸氟西汀治疗20mg/d,一次口服;对照组给予安慰剂,共治疗8周.在治疗前、后分别应用简易智力状态检查量表(MMSE)、护士用住院患者观察量表(NOSIE)进行评分,判定疗效.结果治疗后,治疗组NOSIE评分较对照组有显著性提高(P＜0.01),两组MMSE评分相比无统计学意义(P＞0.05).结论盐酸氟西汀有助于改善血管性痴呆患者的精神行为、提高患者生活质量、减轻护理负担,对患者认知功能无明显影响.

THE CURATIVE EFFECTS OF FLUOXETINE ON VASCULAR DEMENTIA

Objective To evaluate the curative effects of fluoxetine on vascular dementia.Methods Sixty-three cases of vascular dementia were randomly divided into the treatment group and the contrast group.The treatment group was treated with fluoxetine,20mg a day,while the contrast group was treated with placebo,for 8 weeks in both groups.The curative effects were evaluated according to the Mini-mental State Examinatin(MMSE) and the Nurses' Observation Scale for In-patinent Evaluation(NOSIE).Results NOSIE showed significant differences between the two groups(P<0.01),while no significant differences were found between the two groups according to MMSE(P>0.05).Conclusion Fluoxetine can be used to improve psychic dystropy and the living quality of patients without producing obvious effects on their cognitive functions.