中药粉体的物理性质与屈服压力的相关性分析

目的：考察中药粉体物理性质与屈服压力的相关性。方法：利用Heckel方程中屈服压力来表征粉体的可压性。采用多元线性回归分析法考察中药粉体的休止角、崩溃角、平板角、含水量、松密度、振实密度、吸湿性、平均粒径等参数与屈服压力的相关关系。结果：模型药物中屈服压力在52.76~261.64 MPa，其中麦冬、金钱草、五倍子提取物的屈服压力较大，回归方程表明休止角、振实密度、吸湿性、平均粒径与屈服压力呈明显的正相关，崩溃角、平板角、含水量、松密度与屈服压力则呈明显的负相关。结论：中药粉体的物理性质是影响其可压性的重要因素，其中休止角、振实密度、吸湿性和平均粒径对可压性的影响较大。

Correlation Analysis of Physical Properties and Yield Pressure of Traditional Chinese Medicine Powder

Objective: To investigate correlation between physical properties and yield pressure of traditional Chinese medicine powder and to find out main factors affecting compressibility. Method: Compressibility was characterized by yield pressure of Heckel equation.Correlation between physical properties including angle of repose,collapse of angle,flat angle,water content,bulk density,tap density,moisture absorption, average particle size and yield pressure were investigated by multiple regression analysis. Result: Yield pressure of model drugs was in range of 52.76-261.64 MPa,yield pressures of Galla Chinensis extract,Ophiopogonis Radix extract and Lysimachiae Herba extract were greater than other substances.Regression equation showed angle of repose,tap density,moisture absorption and average particle size were positively correlated with yield pressure in measured range,but collapse of angle,flat angle,water content and bulk density were negatively correlated with yield pressure in measured range. Conclusion: Physical properties of traditional Chinese medicine powder had great effect on compressibility,wherein impact of angle of repose,moisture absorption,tap density and average particle size was comparatively great.