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Xp11.2易位/TFE3基因融合相关性肾癌与肾透明细胞癌的螺旋CT诊断鉴别
引用本文:徐晓晨,甘卫东,李笑弓,张古田,刘铁石,姚林方,屈峰,连惠波,张士伟,燕翔,郭宏骞. Xp11.2易位/TFE3基因融合相关性肾癌与肾透明细胞癌的螺旋CT诊断鉴别[J]. 现代泌尿外科杂志, 2012, 17(2): 122-124
作者姓名:徐晓晨  甘卫东  李笑弓  张古田  刘铁石  姚林方  屈峰  连惠波  张士伟  燕翔  郭宏骞
作者单位:徐晓晨 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 甘卫东 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 李笑弓 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 张古田 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 刘铁石 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 姚林方 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 屈峰 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 连惠波 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 张士伟 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 燕翔 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ; 郭宏骞 (南京大学医学院附属鼓楼医院泌尿外科,江苏南京,210008) ;
摘    要:目的评价螺旋CT扫描在Xp11.2易位/TFE3基因融合相关性肾癌和肾透明细胞癌的诊断和鉴别诊断中的应用价值。方法回顾性分析经手术病理证实为Xp11.2易位/TFE3基因融合相关性肾癌和肾透明细胞癌的24例患者的螺旋CT资料。其中Xp11.2易位/TFE3基因融合相关性肾癌和肾透明细胞癌各12例。结果 Xp11.2易位/TFE3基因融合相关性肾癌组和肾透明细胞癌组的平均CT值增强量(即增强扫描动脉相肿瘤最大横截面平均CT值-平扫相上肿瘤最大横截面平均CT值)分别为(31.75±14.73)Hu和(88.30±31.91)Hu,Xp11.2易位/TFE3基因融合性肾癌的CT增强幅度明显小于肾透明细胞癌(P〈0.01)。结论观察病灶的CT值,可以帮助医师初步确定术前肿瘤的病理亚型。

关 键 词:Xp11.2  TFE3  肾透明细胞癌  螺旋CT  CT值

Spiral CT in the differential diagnosis of renal carcinoma associated with Xp11.2 translocation/TFE3 gene fusions and clear cell renal cell carcinoma
XU Xiao-chen,GAN Wei-dong,LI Xiao-gong,ZHANG Gu-tian,LIU Tie-shi,YAO Lin-fang,QU Feng,LIAN Hui-bo,ZHANG Shi-wei,YAN Xiang,GUO Hong-qian. Spiral CT in the differential diagnosis of renal carcinoma associated with Xp11.2 translocation/TFE3 gene fusions and clear cell renal cell carcinoma[J]. Journal of MOdern Urology, 2012, 17(2): 122-124
Authors:XU Xiao-chen  GAN Wei-dong  LI Xiao-gong  ZHANG Gu-tian  LIU Tie-shi  YAO Lin-fang  QU Feng  LIAN Hui-bo  ZHANG Shi-wei  YAN Xiang  GUO Hong-qian
Affiliation:(Department of Urology,the Affiliated Drum Tower Hospital of Medical College of Nanjing University,Nanjing 210008,China)
Abstract:Objective To evaluate the significance of spiral CT scan in diagnosis and differential diagnosis of renal carcinoma associated with Xp11.2 translocation/TFE3 gene fusions and clear cell renal cell carcinoma.Methods We retrospectively analyzed the spiral CT data of 24 cases proved to be Xp11.2 translocation renal carcinoma and clear cell renal cell carcinoma by surgery and pathology.There were 12 cases respectively in the Xp11.2 translocation renal carcinoma group and clear cell renal cell carcinoma group.Results The average enhanced CT value of the Xp11.2 translocation renal carcinoma and clear cell renal cell carcinoma was(31.75±14.73)Hu and(88.30±31.91)Hu respectively,showing significant difference(P<0.01).Conclusion Observing the CT value of the lesions may help to determine the preoperative pathological subtype of the tumor preliminarily.
Keywords:Xp11.2  TFE3  clear cell renal cell carcinoma  spiral CT  CT value
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