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白细胞介素17在慢性丙型肝炎患者免疫损伤中的作用
引用本文:黄建宏,凌文辉,林心,禤彩云,郑通明. 白细胞介素17在慢性丙型肝炎患者免疫损伤中的作用[J]. 国际检验医学杂志, 2013, 34(21): 2819-2820
作者姓名:黄建宏  凌文辉  林心  禤彩云  郑通明
作者单位:珠海市人民医院/暨南大学附属珠海医院检验科,广东珠海519000
基金项目:广东省医学科研基金资助项目(A2012614).
摘    要:
目的 探讨白细胞介素17(IL-17)在慢性丙型肝炎患者免疫损伤中的作用.方法 选择22例慢性丙型肝炎患者作为HCV组,20例健康志愿者作为对照组.分别采用实时聚合酶链反应(RT-PCR)、酶联免疫吸附测定(ELISA)检测血清HCV-RNA及IL-17,其余检测指标包括血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)、凝血酶原时间(PT)、肌酐.结果 HCV组患者血清IL-17水平明显高于对照组(P<0.05).HCV组患者血清ALT、AST及HCV-RNA与血清IL-17水平显著相关(P<0.05).结论 IL-17可能参与了慢性丙型肝炎的免疫学发病机制.

关 键 词:肝炎病毒属  肝炎,丙型  白细胞介素17  肝功能试验

Effects of inerleukin-17 on immunologic injury of patients with chronic hepatitis C
Affiliation:Huang Jianhong , Ling Wenhui , Lin Xing , Xuan Caiyun , Zhen Tongming (Department of Clinical Laboratory, Zhuhai Peoplets Hospital/Zhuhai Hospital Affiliated to Jinan University, Zhuhai, Guangdong 519000, China)
Abstract:
Objective To investigate the effects of interleukin-17 on immunologic injury of patients with chronic hepatitis C. Methods Twenty-two patients with chronic hepatitis C were selected to serve as HCV group and 20 healthy volunteers as control group. Real time polymerase chain reaction(RT-PCR) and enzyme-linked immunosorbent assay(ELISA) were utilized to detect serum HCV-RNA and IL-17, respectively. The rest detection indexes include alanine aminotransferase(ALT), aspartate aminotransferase(AST) ,total bilirubin(TBIL),prothrombin time(PT) and creatinine. Results Serum IL-17 level of patients in HCV group was significant higher than that in control group(P〈0.05). Serum ALT,AST and HCV-RNA of patients in HCV group showed a marked correlation with serum IL-17 (P〈 0. 05). Conclusion IL-17 may involved in immunological pathogenesis of chronic hepatitis C.
Keywords:hepacivirus  hepatitis C  interleukin-17  liver function tests
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