| 苦参碱固体脂质纳米粒的制备和处方优化 |
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| 引用本文： | 李莹莹,孙冰冰,张廷廷,李松涛,赵红玲,王汝兴.苦参碱固体脂质纳米粒的制备和处方优化[J].中成药,2020(1):12-15. |
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| 作者姓名： | 李莹莹 孙冰冰 张廷廷 李松涛 赵红玲 王汝兴 |
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| 作者单位： | ;1.承德医学院中药研究所河北省中药研究与开发重点实验室 |
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| 基金项目： | 河北省自然科学基金项目(H2017406022);河北省高等学校科学技术研究重点项目(ZD2017003);河北省高校重点学科建设项目(冀教高[2013]4);承德医学院高层次人才科研启动基金(201705) |
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| 摘 要： | 目的制备苦参碱固体脂质纳米粒,并进行处方优化。方法选择硬脂酸作为固体脂质,吐温-80作为乳化剂,高压均质法制备苦参碱固体脂质纳米粒。以吐温-80用量、均质压力、药脂比为影响因素,包封率为评价指标,正交试验优化制备工艺。结果最佳处方为吐温-80用量0.3 g,均质压力90 MPa,药脂比1∶5,包封率(94.15±1.44)%。结论该方法简便可靠,可用于制备苦参碱固体脂质纳米粒。
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| 关 键 词： | 苦参碱 固体脂质纳米粒 制备 处方 高压均质法 正交试验 |
Preparation and formulation optimization of matrine solid lipid nanoparticles |
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| LI Ying-ying,SUN Bing-bing,ZHANG Ting-ting,LI Song-tao,ZHAO Hong-ling,WANG Ru-xing.Preparation and formulation optimization of matrine solid lipid nanoparticles[J].Chinese Traditional Patent Medicine,2020(1):12-15. |
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| Authors: | LI Ying-ying SUN Bing-bing ZHANG Ting-ting LI Song-tao ZHAO Hong-ling WANG Ru-xing |
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| Institution: | (Hebei Provincial Key Laboratory for Research and Development of Chinese Materia Medica,Institute for Chinese Materia Medica,Chengde Medical University,Chengde 067000,China) |
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| Abstract: | AIM To prepare matrine solid lipid nanoparticles and to make formulation optimization.METHODS Taking stearic acid as solid lipid and Tween-80 as emulsifier, the solid lipid nanoparticles were prepared by high-pressure homogenization method. With Tween-80 consumption, homogenization pressure and drug-lipid ratio as influencing factors, encapsulation efficiency as an evaluation index, the preparation process was optimized by orthogonal test.RESULTS The optimal formulation was determined to be 0.3 g for Tween-80 consumption, 90 MPa for homogenization pressure, and 1∶5 for drug-lipid ratio, the encapsulation efficiency was(94.15±1.44)%.CONCLUSION This simple and reliable method can be used for the preparation of matrine solid lipid nanoparticles. |
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| Keywords: | matrine solid lipid nanoparticles preparation formulation high?pressure homogenization method orthogonal test |
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