妊娠期糖尿病患者网膜素-1与新生儿体质量的相关性研究

目的探讨妊娠期糖尿病（gestational diabetes mellitus，GDM）足月妊娠患者血清网膜素-1水平变化及其与新生儿体质量的相关性。方法采用ELISA法检测60例GDM孕妇（GDM组），60例糖耐量试验正常孕妇（对照组）血清网膜素-1以及分娩后脐静脉血清中网膜素-1水平；测量新生儿体质量及身高，分析网膜素-1与新生儿体质量、身高的相关性。结果GDM组母体及脐带血清网膜素-1水平低于对照组（P〈0．05）；GDM组新生儿体质量高于对照组（P〈0．05），2组新生儿身高比较差异无统计学意义（P〉0．05）；脐带血清网膜素-1水平与新生儿体质量呈负相关（r=-0．213，P=0．033）。结论血清网膜素-1降低可能是GDM发生、发展的重要环节，脐带血清网膜素-1水平是影响新生儿体质量的因素之一。

Correlation between retinal omentin-1 level and neonatal birth weight in patients with gestational diabetes mellitus

Objective To explore the changes of retinal omentin-1 level in patients with gestational diabetes mellitus （GDM）, and the correlation between retinal omentin-1 and neonatal birth weight. Methods ELISA technique was adopted to detect the level of serum retinal omentin-1 in maternal serum and in umbilical vein in 60 GDM pregnant women （GDM group） and 60 pregnant women with normal glucose tolerance test （control group）. The neonatal birth weight and height were measured. The relationship of retinal omentin-1 with the neonatal birth weight and height was analyzed. Results The levels of retinal omentin-1 in maternal serum and umbilical vein were lower in GDM group than those in control group （P〈0.05）. The neonatal birth weight was higher in GDM group than that in control group （P〈0.05）. There was no significant difference in neonatal birth height （P〉0.05）. The serum retinal omentin-1 level in umbilical vein was negatively correlated with neonatal birth weight （r=-0. 213, P = 0. 033）. Conclusions The decreased serum retinal omentin-1 level may play an important role in the development and progression of GDM, and serum retinal omentin-1 level in umbilical vein is one of the influence factors of neonatal birth weight.