血清高尔基体蛋白73和甲胎蛋白在肝细胞肝癌诊断中价值

目的探讨血清高尔基体蛋白73（Golgi protein 73，GP73）和甲胎蛋白（alpha—fetoprotein，AFP）对肝细胞肝癌（hepatocellular carcinoma，HCC）的诊断价值。方法150例HCC患者为HCC组，108例慢性肝炎患者为慢性肝炎组，100例体检健康者为对照组，采用双抗体夹心酶联免疫法检测3组血清GP73水平，采用电化学发光免疫分析法检测AFP水平。结果HCC组血清GP73（212．8（87．0，279．1）μg／L）、AFP（5212．8（1587，22279．1）μg／L）水平高于慢性肝炎组（55．3（27．0，83．2）μg／L和3．5（1．7，15．5）μg／L）和对照组（52．9（17．0，80．4）μg／L和2．9（1．5，14．7）μg／L）（P均〈0．05）；HCC组GP73、AFP阳性率分别为69％和70％，二者联合检测诊断HCC的敏感性为83％。结论血清GP73在HCC中高表达，可鉴别肝脏的良、恶性疾病，与AFP联合检测可提高检出率。

Value of serum Golgi protein 73 and alfa-fetoprotein to the diagnosis of hepatocellular carcinoma

Objective To investigate the value of serum Golgi protein 73 （GP73） and alpha-fetoprotein （AFP） to the diagnosis of hepatocellular carcinoma （HCC）. Methods A total of 150 patients with HCC （HCC group）, 108 patients with chronic hepatitis （hepatitis group） and 100 health volunteers （control group） were detected GP73 level by ELISA technique and AFP level by electrochemiluminescence immunoassay. Results The GP73 and AFP levels were higher in HCC group （212.8（87.0,279.1） μg/L,5 212.8 （1 587,22 279. 1） μg/L） than those in hepatitis group （55.3（27.0, 83.2） μg/L, 3. 5 （1. 7,15. 5） μg/L） and control group （52.9 （17.0,80.4） μg/L, 2.9 （1.5, 14.7） μg/L）（P〈0.05）. The positive rates of GP73 and AFP were 69% and 70G for HCC group, and the sensitivity of combined detection of GP73 and AFP was 83G. Conclusions GP73 is highly expressed in HCC, which can be used in the differential diagnosis of benign and malignant liver diseases. The combined detection of GP73 and AFP can improve the detection rate of HCC.