宫颈癌广泛性全子宫切除术后下肢深静脉血栓形成原因分析

目的 分析因宫颈癌行广泛性全子宫切除的患者术后发生下肢深静脉血栓的高危因素.方法总结本院2009年至2011年收治的32例因宫颈癌行广泛性全子宫切除术后发生下肢深静脉血栓（deep vein thrombosis,DVT）形成的患者情况,同时筛选了同时期年龄、病变分期相匹配的56例因宫颈癌行广泛性全子宫切除术的患者作为对照组,使用线性回归分析两组之间的差异,计数资料用相对数表示,有序资料比较采用秩和检验.结果 DVT组与对照的平均手术时间为（3.5 ±1.2）小时和（3.0±0.8）小时,围手术期化疗患者占比为35％和23％,术中失血量为（645±120） ml和（400 ±200） ml,三项指标差异均具有统计学意义（P＜0.05）;但患者年龄和疾病分期无明显差异.结论 手术时间较长、术中出血较多、围手术期接受化疗为宫颈癌行广泛性全子宫切除的患者罹患静脉血栓的高危因素.早发现、早治疗能获得较好的治疗效果.

The analysis of deep vein thrombosis of lower limb in cervical cancer patients after extensive total hysterectomy

Objective To analyze the risk factors of patients who were suffering deep vein thrombosis （DVT） devel- oped from cervical cancer after extensive total hysterectomy. Method We summarized 32 cases suffering cervical cancer that developed DVT after extensive total hysterectomy who admitted to our hospital in 2009 -2011, and at the same time, 56 cases of cervical cancer after extensive total hysterectomy that were matched in respect of age, lesion staging were screened and selected as the control group. Linear regression was applied to analyze the potential difference, with count da- ta measured by relative number, and rank sum test was used for ordinal data. Result Mean operative time, patients re- ceiving perioperative chemotherapy （ % ） and intraoperative blood loss of DVT group vs control group were （ 3.5 ± 1.2 ） hoursvs （3.0±0.8） hours （P〈0.05）, 35% vs23%, （P〈0.05）, and （645±120） ml vs （400±200） ml （P〈 0. 05 ）, and there were statistical differences between the two groups regarding the three measurements; while the differ- ences on disease stage and age were not obvious. Conelusion The statistical analysis shows that, longer operalion time, more blood loss and perioperative chemotherapy are risk factors for DVT patients after extensive total hysterectomy. Betterprognosis is expected if early diagnosis and treatment are carried out.