Paraneoplastic subacute cerebellar degeneration in Hodgkin's disease Report of three cases and review of the literature

12 cases of paraneoplastic cerebellar degeneration with Hodgkin's disease have so far been reported. Three additional patients (Stage II-IA / IIA / IIIB) are presented. Although CT and MR-imaging (MRI) revealed a marked cortical atrophy of the cerebellum, there was no evidence of direct brain involvement. After irradiation and chemotherapy all patients showed a complete remission. There was no evidence of primary disease after an observation period of 3/2/5 years. Cerebellar symptoms also showed a partial remission.

As compared to the literature, our treatment appears to be more favourable, probably due to the fact, that therapy was more aggressive than usual.