| 增殖细胞核抗原(PCNA)与胃癌预后关系的免疫组化研究 |
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| 引用本文： | 薛玲②,周慕珩,吴惠茜.增殖细胞核抗原(PCNA)与胃癌预后关系的免疫组化研究[J].中山大学学报(医学科学版),1994(4). |
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| 作者姓名： | 薛玲② 周慕珩 吴惠茜 |
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| 作者单位： | 中山医科大学病理学教研室 |
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| 摘 要： | 应用ＳＬＡＢ免疫酶标法在石蜡切片上半定量分析增殖细胞核抗原（ＰＣＮＡ）的表达与７３例胃癌患者预后的关系，探讨其临床应用价值。结果表明，以ＰＣＮＡ阳性细胞５０％为界线，阳性率＞５０％者术后生存期较短，５年生存率较低，而淋巴结转移率则较高。提示ＰＣＮＡ检测可作为胃癌预后判断的良好指征。
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| 关 键 词： | 增殖细胞核抗原 胃肿瘤 预后 |
IMMUNOHISTOCHEMICAL STUDY ON RELATIONSHIPBETWEEN PCNA AND PROGNOSISOF GASTRIC CARCINOMA |
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| Xue Ling, Zhou Muheng, Wu Huixi.IMMUNOHISTOCHEMICAL STUDY ON RELATIONSHIPBETWEEN PCNA AND PROGNOSISOF GASTRIC CARCINOMA[J].Journal of Sun Yatsen University(Medical Sciences),1994(4). |
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| Authors: | Xue Ling Zhou Muheng Wu Huixi |
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| Abstract: | xpression of proliferating cell nuclear antigen (PCNA ) in 73 cases of gastric carcinoma and its relationship to prognosis were semiquantitatively analysed by SLAB immunohis- tochemical method , and its clinical application was explored. The results showed that the . patients with > 50% PCNA positive rate correlated to a decreased survival , but higher rate of lymph node metastasis than that with < 50% positive rate. Our data suggested that PC- NA can be regarded as a significant prognostic indicator in gastric carcinoma. |
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| Keywords: | proliferating cell nuclear antigen stomach neoplasm prognosis |
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