Facile Synthesis of Core–shell Magnetic Mesoporous Silica Nanoparticles for pH‐sensitive Anticancer Drug Delivery |
| |
| Authors: | Wen‐fei Dong Xin Zhang Xiao Zheng Xuan‐ang Xiao Ying‐shuai Wang Xue Zhao Ming Zhang Jing Li Qi‐sheng Huo Li Chen |
| |
| Affiliation: | 1. CAS Key Laboratory of Bio‐Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China;2. Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun, China;3. State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, China;4. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, China;5. School of Nursing, Jilin University, Changchun, China |
| |
| Abstract: | ![]()
The facile synthesis of core–shell magnetic mesoporous silica nanoparticles (Fe3O4@mSiO2 NPs) was reported in aqueous phase using cetyltrimethylammonium bromide as a template under alcohol‐free conditions. Compared to the conventional synthesis method for core–shell Fe3O4@mSiO2 NPs, the approach in this study is rapid (only 5‐min reaction time), cheap (without using organic agents), and environmentally friendly (one‐step synthesis in alcohol‐free medium). Doxorubicin (DOX)‐loaded Fe3O4@mSiO2 NPs exert extraordinarily high specificity for liver cancer cells, which was due to the pH‐sensitive doxorubicin release, as well as higher endocytosis capacity in liver cancer cells rather than normal liver cells. The potential advantages of using such Fe3O4@mSiO2 NPs as the vehicle of anticancer drugs were that the Fe3O4@mSiO2 NPs exhibit good biocompatibility, high loading and protection of the guest molecules, selective killing effect, and efficient cellular uptake. The exciting pH‐dependent release properties of doxorubicin‐loaded Fe3O4@mSiO2 NPs make their use a promising strategy for enhancing efficient therapy toward tumors, while reducing the cytotoxicity of doxorubicin to human normal neutral tissue or cells. |
| |
| Keywords: | core– shell facile liver cancer therapy magnetic mesoporous silica selective |
|
|
