CD147在唾液腺腺样囊性癌中的表达及临床意义

目的：研究CD147在唾液腺腺样囊性癌（adenoid cystic carcinoma，ACC）中的表达及与腺样囊性癌临床病理特征、患者预后的关系。方法：采用免疫组化Envision^TM法检测72例唾液腺腺样囊性癌组织和20例正常唾液腺组织CD147的表达，应用SPSS16．0软件包对实验数据进行统计学分析。结果：CD147在腺样囊性癌中表达阳性率为62．5％，显著高于正常唾液腺组（25．0％），P〈0．01。CD147表达与腺样囊性癌大小、病理分型、临床分期、神经侵袭、血管侵袭及肿瘤转移显著相关（P〈0．05），与患者性别、年龄及肿瘤复发无显著性相关忪0．05）。单因素分析显示．CD147表达强阳性组累积生存率显著低于弱阳性及阴性表达组（P〈0.0001）。多因素分析显示，CD147表达及肿瘤病理分型、血管侵袭、肿瘤转移是影响腺样囊性癌患者总生存期的独立预后因素（P〈0．05）。结论：CD147的表达与腺样囊性癌临床病理特征密切相关，对腺样囊性癌诊断和预后评估有重要参考价值。

Expression and clinical significance of CD147 in adenoid cystic carcinoma of salivary gland

PURPOSE： To investigate the expression of CD147 in adenoid cystic carcinoma （ACC） of the salivary gland, and its correlation with patients＇ clinicopathological characteristics and prognosis. METHODS： Immunohistochemical （EnvisionTM） technique was used to examine the expression of CD147 in 72 ACC cases and 20 normal salivary gland tissues. SPSSI6.0 software package was employed to analyze the data statistically. RESULTS： The expression of CD147 in ACC was 62.5%, significantly higher than that in normal salivary gland tissues （P〈0.01）. The expression of CD147 significantly correlated with tumour size, pathologic type, clinical stage, perineural invasion, vascular invasion and distant metastasis （P〈0.05）, but not with age, gender and tumor recurrence （P〉0.05）. Univariate analysis showed that the cumulative survival rate was significantly lower in patients with strong expression of CD147 than in patients with moderate or negative expression （P〈0.0001）. Multivariate analysis indicated that CD147 expression, pathologic type, vascular invasion and distant metastasis were all independent predictors of overall survival time （P〈0.05）. CONCLUSION： CD147 expression significantly correlates with the clinicopathological characteristics of ACC. It may serve as a valuable marker for diagnosis and an indicator for prognosis of ACC.