灯盏细辛注射液对急性脑梗死患者血清粘附分子sICAM-1和CD11b/CD18的影响

目的 观察灯盏细辛注射液对急性脑梗死(acute cerebral infaction,ACI)患者的临床疗效及对血清粘附分子sICAM-1和CD11b/CD18表达的对影响.方法 69例ACI患者随机分为灯盏细辛治疗组(36例)和常规治疗组(33例),采用双抗体夹心ELISA法、流式细胞仪(FCM)检测两组ACI患者治疗前后血清粘附分子sICAM-1和CD11b/CD18表达的水平.结果 ACI患者治疗前血清粘附分子sICAM-1和CD11b/CD18的表达水平显著高于健康人组(p＜0.05),灯盏细辛治疗组临床有效率明显高于常规治疗组(P＜0.05),两组治疗后血清粘附分子sICAM-1和CD11b/CD18的表达均明显下降,灯盏细辛治疗组降低较常规治疗组更明显(p＜0.05).结论 灯盏细辛注射液治疗ACI可能与其下调血清粘附分子sICAM-1和CD11b/CD18的表达,减轻中枢神经系统的炎性损伤密切相关.

Effect of Erigeron Injection on Expresions of Adhesion molecules CD11b/CD18 and Solution Cell Adhesion Molecule-1 in Peripheral Blood of Patients with Acute Cerebral Infarction(ACI)

Objective To investigate the clinical effect of Erigeron Injection for acute cerebral infarction(ACI) and its influence on expresions of adhesion molecules CD11b/CD18 and solution cell adhesion molecule-1 in peripheral blood of patients with ACI. Methods Sixty-nine patients with ACI were randomly divided intotreated group and the conventional control group, expression of adhesion molecules CD11b/CD18 was measuredby flow cytometry(FCM), the expression of solution cell adhesion molecule-1 were measured serially with two-layer antibody sandwich ELISA before and after treatment . Results Expressions of adhesion moleculesCD11b/CD18 and solution cell adhesion molecule-1 in the patients before treatment were all obviously higherthan those in the normal control group(p<0.05). The total curative effect in the treated group weresignificantly higher than in the contral group. All the two parameters were significantly decreased aftertreatment,and the lowering in the treated group was more significant than in the control group(p<0.05).Conclusion The effection of Erigeron Injection on ACI patients may relate to its action in down-regulatingthe expression of adhesion molecules CD11b/CD18 and solution cell adhesion molecule-1 ,allevating theinflammatory injury of central nervous system.