Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma |
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| Authors: | Muller D Millon R Théobald S Hussenet T Wasylyk B du Manoir S Abecassis J |
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| Affiliation: | Laboratoire de Biologie Tumorale, Centre de lutte contre le cancer Paul Strauss, 3 rue de la Porte de l'H?pital, 67065 Strasbourg Cedex, France. btumorale@strasbourg.fnclcc.fr |
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| Abstract: | We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25-28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumours (26%) with no relationships to the clinico-pathological parameters. The Cyclin L1 antibody we developed labels nuclear speckles in tumour cells compatible with a role for CCNL1 in RNA splicing. |
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| Keywords: | head and neck squamous cell carcinoma cyclin L1 CCNL1 chromosome 3q HNSCC |
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