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体外联合用药对多重耐药铜绿假单胞菌抗菌活性的研究
引用本文:郑荣,曹伟,李彩霞. 体外联合用药对多重耐药铜绿假单胞菌抗菌活性的研究[J]. 中国现代医学杂志, 2008, 18(6): 813-815
作者姓名:郑荣  曹伟  李彩霞
作者单位:中南大学湘雅二医院,检验科,湖南,长沙,410011
摘    要:
目的探讨头孢他啶、美罗培南、加替沙星、环丙沙星、左氧氟沙星、丁胺卡那体外联合应用对多重耐药铜绿假单胞菌的抗菌效应,为临床用药提供实验依据。方法采用棋盘法设计,微量肉汤稀释法测定,计算FIC指数,判定联合效应。结果头孢他啶、美罗培南和左氧氟沙星联合应用对铜绿假单胞菌的体外抗菌协同作用分别为25%和18.8%,相加作用分别为59.4%和59.4%,无关作用分别为15.6%和21.8%,无拮抗效应,其他组合均不理想。结论所有组合中,头孢他啶、美罗培南与左氧氟沙星联合应用,有显著效果,且它们联合应用,对多重耐药铜绿假单胞菌的体外抗菌作用以协同和相加作用为主,无关作用较少,无拮抗效应。

关 键 词:铜绿假单胞菌  多重耐药  抗生素联合  FIC  联合用药  多重耐药铜绿假单胞菌  抗菌活性  研究  in vitro  pseudomonas aeruginosa  resistant  combination  antibiotic  effects  效果  组合  拮抗效应  相加作用  协同作用  体外抗菌  南和  结果  联合效应  指数
文章编号:1005-8982(2008)06-0813-03
修稿时间:2007-10-16

Study on effects of antibiotic combination against multi-drug resistant pseudomonas aeruginosa in vitro
ZHENG Rong,CAO Wei,LI Cai-xia. Study on effects of antibiotic combination against multi-drug resistant pseudomonas aeruginosa in vitro[J]. China Journal of Modern Medicine, 2008, 18(6): 813-815
Authors:ZHENG Rong  CAO Wei  LI Cai-xia
Affiliation:ZHENG Rong,CAO Wei,LI Cai-xia (Department of Clinical Laboratory,Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,P.R.China)
Abstract:
[Objective] To estimate the effects of the combination of Ceftazidime,Meropenem,Gatifloxacin,Ciproflxacin,Amikacin and Levofloxacin to multi-drug resistance psendomonas aeruginosa,and provide experimental data for their clinical practice. [Methods] The protocol was designed by checkerboard method and the MICS of antibiotics were admitted by microdilution broth method,the FIC index was calcutated according to MIC results. [Results] The reults showed that the effects of Ceftazidime or Meropenem with Levofolxa...
Keywords:pseudomonas aeruginosa  multi-drug resistant  antibiotic combination  fractional inhibitory concentration  
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