芦荟混合液雾化防治放射性口腔黏膜反应的疗效观察

目的探讨鼻咽癌（NPC）放射性口腔黏膜反应的有效防治措施。方法将120例NPC需放疗患者随机分为观察组（n=61）及对照组（n=59）,观察组于放疗前3d用20%芦蜜液含漱,含漱液在口腔内保持10～15min,3次/d,每次放疗结束用50%芦荟混合液雾化20～30min,至放疗结束;对照组于放疗前3d用朵贝氏液含漱,3次/d,至放疗结束,放疗中患者出现口腔黏膜反应时予庆大霉素,地塞米松雾化和对症治疗。结果观察组明显推迟口腔黏膜反应出现时间,缩短黏膜修复时间,口腔黏膜反应程度为Ⅰ～Ⅱ级,与对照组比较差异有统计学意义（P〈0.05）。结论芦荟混合液雾化对防治放射性口腔黏膜反应有较好的效果,其取材方便,经济,无毒副作用,值得临床推广应用。

Observation on curative effect of atomization of compound aloe solution in prevention and treatment of radiotherapy-induced oral mucositis reaction

Objective To investigate the effective measures to prevent and treat the radiotherapy- induced oral mucositis reaction among patients with nasopharyngeal carcinoma （NPC）. Methods 120 cases with NPC were randomly divided into the observation group （n = 61） and the control group （n = 59）. In the observation group, the patients washed their mouths with 20% aloe solution three days before the radiotherapy and kept the aloe solution in the mouth for 10-15 minutes three times per day. The patients received the atomization of 50% compound aloe solution for 20-30 minutes after every time of ra- diotherapy until the radiotherapy completely finished. While in the control group, the patients washed their mouths with compound Boras solution three days before radiotherapy three times a day, until all radiotherapy finished. In the control group, the patients were given gentamicin and dexamethasone if oral mucositis appeared. Results Inthe treatment group, oral mucositis was delayed and membrane recovery time was shorten. The oral mucositis grade were Ⅰ～Ⅱ. There was a statistic significance compared with the control group （P〈0.05）. Conclusions Atomization of compound aloe solution is effective to prevent and treat the radiotherapy-induced oral mucositis reaction. It is easy to get the materials, economic and has no side effects. So it is valuable for clinical application.